Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, United Kingdom.
Anal Chem. 2022 Oct 4;94(39):13540-13548. doi: 10.1021/acs.analchem.2c02884. Epub 2022 Sep 21.
This manuscript details the first report of a complete additively manufactured rotating disk electrode setup, highlighting how high-performing equipment can be designed and produced rapidly using additive manufacturing without compromising on performance. The additively manufactured rotating disk electrode system was printed using a predominantly acrylonitrile butadiene styrene (ABS) based filament and used widely available, low-cost electronics, and simplified machined parts to create. The additively manufactured rotating disk electrode system costs less than 2% of a comparable commercial solution (£84.47 ($102.26) total). The rotating disk electrode is also additively manufactured using a carbon black/polylactic acid (CB/PLA) equivalent, developing a completely additively manufactured rotating disk electrode system. The electrochemical characterization of the additively manufactured rotating disk electrode setup was performed using hexaamineruthenium(III) chloride and compared favorably with a commercial glassy carbon electrode. Finally, this work shows how the additively manufactured rotating disk electrode experimental system and additive manufactured electrodes can be utilized for the electroanalytical determination of levodopa, a drug used in the treatment of Parkinson's disease, producing a limit of detection of 0.23 ± 0.03 μM. This work represents a step-change in how additive manufacturing can be used in research, allowing the production of high-end equipment for hugely reduced costs, without compromising on performance. Utilizing additive manufacturing in this way could greatly enhance the research possibilities for less well-funded research groups.
这篇手稿详细介绍了首个完全增材制造旋转盘电极装置的报告，重点介绍了如何使用增材制造快速设计和生产高性能设备，而不会牺牲性能。增材制造旋转盘电极系统使用主要基于丙烯腈丁二烯苯乙烯（ABS）的灯丝进行打印，并使用广泛可用的低成本电子设备和简化的机械部件进行制造。增材制造旋转盘电极系统的成本不到可比商业解决方案的 2%（总计 84.47 英镑（102.26 美元））。旋转盘电极也使用等效的碳黑/聚乳酸（CB/PLA）进行增材制造，从而开发出完全增材制造的旋转盘电极系统。使用六氨合钌(III)氯化物对增材制造旋转盘电极装置进行了电化学表征，并与商业玻璃碳电极进行了很好的比较。最后，这项工作展示了如何利用增材制造旋转盘电极实验系统和增材制造电极来进行左旋多巴的电分析测定，左旋多巴是一种用于治疗帕金森病的药物，产生的检测限为 0.23±0.03μM。这项工作代表了增材制造在研究中的应用的重大转变，允许以更低的成本生产高端设备，而不会牺牲性能。以这种方式利用增材制造可以极大地增强资金较少的研究小组的研究可能性。
