Crapnell Robert D, Banks Craig E
Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, United Kingdom.
ACS Meas Sci Au. 2023 Feb 3;3(2):84-97. doi: 10.1021/acsmeasuresciau.2c00071. eCollection 2023 Apr 19.
L-DOPA (levodopa) is a therapeutic agent which is the most effective medication for treating Parkinson's disease, but it needs dose optimization, and therefore its analytical determination is required. Laboratory analytical instruments can be routinely used to measure L-DOPA but are not always available in clinical settings and traditional research laboratories, and they also have slow result delivery times and high costs. The use of electroanalytical sensing overcomes these problems providing a highly sensitivity, low-cost, and readily portable solution. Consequently, we overview the electroanalytical determination of L-DOPA reported throughout the literature summarizing the endeavors toward sensing L-DOPA, and we offer insights into future research opportunities.
左旋多巴是一种治疗药物，是治疗帕金森病最有效的药物，但需要进行剂量优化，因此需要对其进行分析测定。实验室分析仪器可常规用于测量左旋多巴，但在临床环境和传统研究实验室中并不总是可用，而且它们的结果交付时间也很慢，成本很高。使用电分析传感克服了这些问题，提供了一种高灵敏度、低成本且易于携带的解决方案。因此，我们综述了文献中报道的左旋多巴的电分析测定方法，总结了检测左旋多巴的研究成果，并对未来的研究机会提供了见解。
