Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain.
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Dr. Aiguader 88, 08003 Barcelona, Spain.
Curr Opin Cell Biol. 2022 Oct;78:102130. doi: 10.1016/j.ceb.2022.102130. Epub 2022 Sep 18.
Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here, we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential advantages that signaling oscillations might have in cell function. The biological processes considered include cellular differentiation and tissue maintenance, intermittent responses in pluripotent stem cells, and collective cell migration during wound healing. With the aid of mathematical modeling, we review recent examples in which delayed negative feedback has been seen to act as a unifying principle that underpins this wide variety of phenomena.
越来越多的证据表明，震荡活动在细胞信号中广泛存在。在这里，我们回顾了一些最新的证据，重点关注可能潜在存在于这种动态行为背后的分子机制，以及信号震荡在细胞功能中可能具有的优势。所考虑的生物过程包括细胞分化和组织维持、多能干细胞的间歇性反应，以及伤口愈合过程中的细胞集体迁移。借助数学建模，我们回顾了最近的一些例子，其中延迟负反馈被视为一种统一原则，支撑着广泛的现象。
