Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada; Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.
Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada; Department of Medicine, Division of Neurology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5H3, Canada.
Cell Rep Med. 2022 Sep 20;3(9):100742. doi: 10.1016/j.xcrm.2022.100742.
Diets rich in added sugars are associated with metabolic diseases, and studies have shown a link between these pathologies and changes in the microbiome. Given the reported associations in animal models between the microbiome and brown adipose tissue (BAT) function, and the alterations in the microbiome induced by high-glucose or high-fructose diets, we investigated the potential causal link between high-glucose or -fructose diets and BAT dysfunction in humans. Primary outcomes are changes in BAT cold-induced thermogenesis and the fecal microbiome (clinicaltrials.gov, NCT03188835). We show that BAT glucose uptake, but not thermogenesis, is impaired by a high-fructose but not high-glucose diet, in the absence of changes in the gastrointestinal microbiome. We conclude that decreased BAT glucose metabolism occurs earlier than other pathophysiological abnormalities during fructose overconsumption in humans. This is a potential confounding factor for studies relying on F-FDG to assess BAT thermogenesis.
富含添加糖的饮食与代谢性疾病有关，研究表明这些病理学与微生物组的变化之间存在联系。鉴于动物模型中微生物组与棕色脂肪组织（BAT）功能之间的关联，以及高葡萄糖或高果糖饮食引起的微生物组改变，我们研究了高葡萄糖或高果糖饮食与人类 BAT 功能障碍之间的潜在因果关系。主要结果是 BAT 冷诱导产热和粪便微生物组的变化（clinicaltrials.gov，NCT03188835）。我们表明，在胃肠道微生物组没有变化的情况下，高果糖饮食而非高葡萄糖饮食会损害 BAT 的葡萄糖摄取，但不会损害产热。我们的结论是，在人类果糖过度摄入期间，BAT 葡萄糖代谢的减少早于其他病理生理异常发生。这是依赖 F-FDG 评估 BAT 产热的研究的一个潜在混杂因素。
