Group of Study in Endocrinology and Metabolism, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.
School of Medicine and Nutrition, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk L39 4QP, UK.
Nutrients. 2024 Mar 25;16(7):939. doi: 10.3390/nu16070939.
Worldwide, childhood obesity cases continue to rise, and its prevalence is known to increase the risk of non-communicable diseases typically found in adults, such as cardiovascular disease and type 2 diabetes mellitus. Thus, comprehending its multiple causes to build healthier approaches and revert this scenario is urgent. Obesity development is strongly associated with high fructose intake since the excessive consumption of this highly lipogenic sugar leads to white fat accumulation and causes white adipose tissue (WAT) inflammation, oxidative stress, and dysregulated adipokine release. Unfortunately, the global consumption of fructose has increased dramatically in recent years, which is associated with the fact that fructose is not always evident to consumers, as it is commonly added as a sweetener in food and sugar-sweetened beverages (SSB). Therefore, here, we discuss the impact of excessive fructose intake on adipose tissue biology, its contribution to childhood obesity, and current strategies for reducing high fructose and/or free sugar intake. To achieve such reductions, we conclude that it is important that the population has access to reliable information about food ingredients via food labels. Consumers also need scientific education to understand potential health risks to themselves and their children.
在全球范围内，儿童肥胖病例持续上升，众所周知，肥胖的流行会增加成年人常见的非传染性疾病的风险，如心血管疾病和 2 型糖尿病。因此，理解其多种原因，制定更健康的方法并扭转这种局面迫在眉睫。肥胖的发展与高果糖摄入密切相关，因为这种高度生脂糖的过量摄入会导致白色脂肪堆积，并导致白色脂肪组织 (WAT) 炎症、氧化应激和失调的脂肪因子释放。不幸的是，近年来全球果糖的消耗量急剧增加，这与果糖并不总是对消费者明显的事实有关，因为它通常作为甜味剂添加到食品和含糖饮料 (SSB) 中。因此，在这里，我们讨论了过量摄入果糖对脂肪组织生物学的影响，它对儿童肥胖的贡献，以及目前减少高果糖和/或游离糖摄入的策略。为了实现这些减少，我们的结论是，重要的是让人们通过食品标签获得有关食品成分的可靠信息。消费者还需要接受科学教育，以了解对自己和孩子的潜在健康风险。
