补体在趋化作用中的作用：局部感染的研究
Role of complement in chemotaxis: study of a localized infection.
作者信息
Wilson D M, Ormrod D J, Miller T E
出版信息
Infect Immun. 1980 Jul;29(1):8-12. doi: 10.1128/iai.29.1.8-12.1980.
A model of Escherichia coli-induced pyelonephritis was used to study the effect of complement depletion in an organ-specific, nonimmunological inflammatory lesion in rats. In this model of a local infection, which can be considered to be nonspecific inflammatory stimulus, the depletion of complement by the administration of a purified cobra venom factor did not alter the course of the disease. There were minor differences when the results from complement-depleted and normocomplementemic animals were compared, but the composition of the inflammatory infiltrate was not greatly altered. Therefore, the presence of C3 and a functional complement system are relatively unimportant factors in determining the characteristics of the inflammatory response in a localized infection-induced lesion.
利用大肠杆菌诱导的肾盂肾炎模型，研究补体耗竭对大鼠器官特异性非免疫性炎症损伤的影响。在这种局部感染模型中，可将其视为非特异性炎症刺激，通过给予纯化的眼镜蛇毒因子来耗竭补体，并未改变疾病进程。比较补体耗竭动物和正常补体动物的结果时，存在细微差异，但炎症浸润的组成并未发生很大改变。因此，在确定局部感染诱导损伤中炎症反应的特征时，C3的存在和功能性补体系统是相对不重要的因素。
Zotero 插件