Huang Li, Zhang Yuanchang, Su Enben, Liu Yuan, Deng Yan, Jin Lian, Chen Zhu, Li Song, Zhao Yongxiang, He Nongyue
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University Nanjing 210096 China
Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology Zhuzhou 412007 P. R. China.
Nanoscale Adv. 2019 Dec 17;2(3):1138-1143. doi: 10.1039/c9na00644c. eCollection 2020 Mar 17.
Accurate detection of markers in human serum is important in the early diagnosis of acute myocardial infarction (AMI). This work presents a novel eight biomarker strip, which combines dry chemistry with a fluorescence lateral flow assay. Eight AMI markers were employed simultaneously for sensitive detection, including cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), uric acid (UA), myoglobin (Myo), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI). The strip offers the advantages of simple fabrication, convenience, time-saving detection and accurate assessment for AMI. Moreover, the strip possesses acceptable applicability for human serum. This proposed strategy establishes a remarkable platform for the construction of a multi-target detection strip that is feasible for accurate detection for real human serum samples.
准确检测人血清中的标志物对于急性心肌梗死（AMI）的早期诊断至关重要。这项工作展示了一种新型的八生物标志物试纸条，它将干化学与荧光侧向流动分析相结合。同时使用八种AMI标志物进行灵敏检测，包括胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）、肌红蛋白（Myo）、肌酸激酶同工酶MB（CK-MB）和心肌肌钙蛋白I（cTnI）。该试纸条具有制作简单、方便、检测省时以及对AMI评估准确等优点。此外，该试纸条对人血清具有可接受的适用性。所提出的策略为构建多靶点检测试纸条建立了一个卓越的平台，该试纸条对于实际人血清样本的准确检测是可行的。
Nanoscale Adv. 2019-12-17
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