Ferhan Abdul Rahim, Yoon Bo Kyeong, Jeon Won-Yong, Cho Nam-Joon
School of Materials Science and Engineering, Nanyang Technological University 50 Nanyang Avenue 639798 Singapore
School of Chemical Engineering, Sungkyunkwan University Suwon 16419 Republic of Korea.
Nanoscale Adv. 2020 Jul 2;2(8):3103-3114. doi: 10.1039/d0na00279h. eCollection 2020 Aug 11.
Understanding biointerfacial processes is crucial in various fields across fundamental and applied biology, but performing quantitative studies conventional characterization techniques remains challenging due to instrumentation as well as analytical complexities and limitations. In order to accelerate translational research and address current challenges in healthcare and medicine, there is an outstanding need to develop surface-sensitive technologies with advanced measurement capabilities. Along this line, nanoplasmonic sensing has emerged as a powerful tool to quantitatively study biointerfacial processes owing to its high spatial resolution at the nanoscale. Consequently, the development of robust biological interfacing strategies becomes imperative to maximize its characterization potential. This review will highlight and discuss the critical role of biological interfacing within the context of constructing nanoplasmonic sensing platforms for biointerfacial science applications. Apart from paving the way for the development of highly surface-sensitive characterization tools that will spur fundamental biological interaction studies and improve the overall understanding of biological processes, the basic principles behind biointerfacing strategies presented in this review are also applicable to other fields that involve an interface between an inorganic material and a biological system.
了解生物界面过程在基础生物学和应用生物学的各个领域都至关重要，但由于仪器以及分析的复杂性和局限性，使用传统表征技术进行定量研究仍然具有挑战性。为了加速转化研究并应对医疗保健和医学领域当前的挑战，迫切需要开发具有先进测量能力的表面敏感技术。沿着这条线，纳米等离子体传感由于其在纳米尺度上的高空间分辨率，已成为定量研究生物界面过程的强大工具。因此，开发强大的生物接口策略对于最大限度地发挥其表征潜力变得至关重要。本综述将突出并讨论生物接口在构建用于生物界面科学应用的纳米等离子体传感平台的背景下的关键作用。除了为开发高度表面敏感的表征工具铺平道路，以促进基础生物相互作用研究并增进对生物过程的整体理解之外，本综述中提出的生物接口策略背后的基本原理也适用于其他涉及无机材料与生物系统之间界面的领域。
