Li Wenqiang, Huang Qian, Li Mei, Wen Youli, Chen Zhao, Fan Yuting, Shen Chen, Gong Chen, Luo Yao, Deng Zhiping
Department of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, Zigong, China.
Department of Pulmonary and Critical Care Medicine, Dazhou Dachuan District People's Hospital (Dazhou Third People's Hospital), Dazhou, China.
Front Bioeng Biotechnol. 2025 Jul 31;13:1644007. doi: 10.3389/fbioe.2025.1644007. eCollection 2025.
Since the lungs are directly connected to the external environment and have a rich blood supply, they are susceptible to damage and tumor growth. However, the pharmacokinetics of traditional drugs in the lungs are limited when administered orally or intravenously, posing challenges for clinical treatment. Compared to traditional drug delivery methods, nano-based drug delivery systems (NDDSs) have the advantages of high drug loading capacity, strong targeting, low cellular toxicity, and extended circulation time in the blood. Stimuli-responsive materials, often referred to as "smart" materials, are a class of functional materials that can change their properties in response to various stimuli in both internal and external environments. Therefore, stimuli-responsive materials have gradually become promising candidates for NDDSs. To date, many stimuli-responsive NDDSs have been developed for treating lung diseases. Our review primarily summarizes the novel NDDSs that have emerged in recent years for treating common benign and malignant lesions in the lungs, based on stimuli-responsive materials. Finally, we discussed the existing issues in stimuli-responsive NDDSs and looked forward to their future development prospects.
由于肺部直接与外部环境相连且血液供应丰富，它们易受损伤和肿瘤生长的影响。然而，传统药物经口服或静脉给药时在肺部的药代动力学有限，给临床治疗带来挑战。与传统药物递送方法相比，基于纳米的药物递送系统（NDDSs）具有载药量高、靶向性强、细胞毒性低以及在血液中循环时间延长等优点。刺激响应材料，通常被称为“智能”材料，是一类能够在内部和外部环境中响应各种刺激而改变其性质的功能材料。因此，刺激响应材料已逐渐成为NDDSs的有前景的候选材料。迄今为止，已经开发了许多用于治疗肺部疾病的刺激响应性NDDSs。我们的综述主要总结了近年来基于刺激响应材料出现的用于治疗肺部常见良性和恶性病变的新型NDDSs。最后，我们讨论了刺激响应性NDDSs中存在的问题，并展望了它们未来的发展前景。
