采用电子捕获气相色谱法分析脑组织和尿液中的抗抑郁药苯乙肼。

Analysis of the antidepressant phenelzine in brain tissue and urine using electron-capture gas chromatography.

作者信息

Rao T S, Baker G B, Coutts R T, Yeung J M, McIntosh G J, Torok-Both G A

出版信息

J Pharmacol Methods. 1987 Jul;17(4):297-304. doi: 10.1016/0160-5402(87)90043-x.

DOI:10.1016/0160-5402(87)90043-x

Abstract

A novel gas chromatographic method for the analysis of the antidepressant phenelzine has been developed. The procedure involves extraction with a liquid ion-pairing compound, back-extraction with HCl, basification, and derivatization with pentafluorobenzoyl chloride. The dipentafluorobenzoyl derivative (structure confirmed by mass spectrometry) is separated and analyzed on a gas chromatograph equipped with a fused silica capillary column and an electron-capture detector. The procedure has been utilized for quantitation of phenelzine in brain of phenelzine-treated rats and in urine from human subjects receiving phenelzine.

摘要

已开发出一种用于分析抗抑郁药苯乙肼的新型气相色谱法。该方法包括用液体离子对化合物萃取、用盐酸反萃取、碱化以及用五氟苯甲酰氯衍生化。双五氟苯甲酰衍生物（结构经质谱确认）在配备熔融石英毛细管柱和电子捕获检测器的气相色谱仪上进行分离和分析。该方法已用于定量苯乙肼处理大鼠脑中的苯乙肼以及接受苯乙肼治疗的人类受试者尿液中的苯乙肼。

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