Khorshidi Sajedeh, Younesi Sogol, Karkhaneh Akbar
Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Colloids Surf B Biointerfaces. 2022 Nov;219:112832. doi: 10.1016/j.colsurfb.2022.112832. Epub 2022 Sep 9.
Hypoxia is a serious obstacle in cancer treatment. The aberrant vascular network as well as the abnormal extracellular matrix arrangement results in formation of a hypoxic regions in tumors which show high resistance to the curing. Hypoxia makes the cancer treatment challengeable via two mechanisms; first and foremost, hypoxia changes the cell metabolism and leads the cells towards an aggressive and metastatic phenotype and second, hypoxia decreases the efficiency of the various cancer treatment modalities. Most of the cancer treatment methods including chemotherapy, radiotherapy, photodynamic therapy, sonodynamic therapy and immunotherapy are negatively affected by the oxygen deprivation. Therefore, the regional oxygenation is requisite to alleviate the negative impacts of the hypoxia on tumor cells and tumor therapy modalities. A great deal of effort has been put forth to resolve the problem of hypoxia in tumors. Peroxides have gained tremendous attention as oxygen generating components in cancer therapy. The concurrent loading of the peroxides and cancer treatment components into a single delivery system can bring about a multipurpose delivery system and substantially encourage the success of the cancer amelioration. In this review, we have tried to after the description of a relation between hypoxia and cancer treatment modalities, discuss the role of peroxides in tumor hyperoxygenation and cancer therapy success. Thereafter, we have summarized a number of vehicles for the delivery of the peroxide alone or in combination with other therapeutic components for cancer treatment.
缺氧是癌症治疗中的一个严重障碍。异常的血管网络以及细胞外基质的异常排列导致肿瘤中形成缺氧区域，这些区域对治疗表现出高度抗性。缺氧通过两种机制使癌症治疗具有挑战性；首先也是最重要的，缺氧改变细胞代谢并使细胞趋向于侵袭性和转移表型，其次，缺氧降低了各种癌症治疗方式的效率。包括化疗、放疗、光动力疗法、声动力疗法和免疫疗法在内的大多数癌症治疗方法都受到缺氧的负面影响。因此，局部氧合对于减轻缺氧对肿瘤细胞和肿瘤治疗方式的负面影响是必要的。人们已经付出了巨大努力来解决肿瘤中的缺氧问题。过氧化物作为癌症治疗中的氧气生成成分受到了极大关注。将过氧化物和癌症治疗成分同时负载到单一递送系统中可以产生多功能递送系统，并极大地促进癌症改善的成功。在这篇综述中，我们试图在描述缺氧与癌症治疗方式之间的关系之后，讨论过氧化物在肿瘤高氧合和癌症治疗成功中的作用。此后，我们总结了一些用于单独递送过氧化物或与其他治疗成分联合用于癌症治疗的载体。
