Barbieri Elisa, Porcu Gloria, Petigara Tanaz, Senese Francesca, Prandi Gian Marco, Scamarcia Antonio, Cantarutti Luigi, Cantarutti Anna, Giaquinto Carlo
Division of Pediatric Infectious Diseases, Department of Women's and Children's Health, University of Padova, 35131 Padova, Italy.
Unit of Biostatistics Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.
Children (Basel). 2022 Sep 3;9(9):1347. doi: 10.3390/children9091347.
Despite widespread childhood immunization programs, pneumococcal disease (PD) continues to be associated with significant clinical and economic burden worldwide. This retrospective study assessed the PD-related economic burden in children from the Veneto region of Italy following the introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) to the Italian immunization schedule in 2010. Between 2010 and 2017, the annual incidences of pneumonia, acute otitis media (AOM), and invasive pneumococcal disease (IPD), as well as syndromic-disease-related episodes, declined. In our analysis of data from regional expenditure and healthcare resource utilization (HCRU) databases related to children < 15 years of age, we found that regional expenditures decreased between 2010 and 2017 for pneumonia (EUR 8.88 to EUR 3.59 million), AOM (EUR 3.78 to EUR 2.76 million), and IPD (EUR 1.40 to EUR 1.00 million). Despite reductions in PD-related expenditure following the introduction of PCV13, there continues to be an economic burden associated with PD in Veneto, Italy.
尽管全球广泛实施儿童免疫规划，但肺炎球菌疾病（PD）在全球范围内仍然造成了巨大的临床和经济负担。这项回顾性研究评估了2010年13价肺炎球菌结合疫苗（PCV13）纳入意大利免疫规划后，意大利威尼托地区儿童与PD相关的经济负担。2010年至2017年期间，肺炎、急性中耳炎（AOM）和侵袭性肺炎球菌疾病（IPD）的年发病率以及与综合征疾病相关的发作次数均有所下降。在我们对15岁以下儿童的区域支出和医疗资源利用（HCRU）数据库数据的分析中，我们发现2010年至2017年期间，肺炎（从888万欧元降至359万欧元）、AOM（从378万欧元降至276万欧元）和IPD（从140万欧元降至100万欧元）的区域支出有所减少。尽管引入PCV13后与PD相关的支出有所减少，但意大利威尼托地区与PD相关的经济负担依然存在。
