Hashim S A, Tantibhedyangkul P
Lipids. 1987 Jun;22(6):429-34. doi: 10.1007/BF02537274.
Effects of feeding early in life a diet high in either long chain (LCT) or medium chain triglyceride (MCT) were studied on the development of adipose tissue in post-weanling rats. The diets were similar in calorie distribution and identical in nutrients except for type of fat. The caloric distribution of the two diets by percent was LCT (corn oil)/protein/carbohydrate, 70/18/12 and MCT/corn oil/protein/carbohydrate, 66/4/18/12. Male littermates with less than 5% weight difference were pair-fed the two diets randomly at age 18-20 days. One-fourth of the rats were killed at 10, 16, 22 and 28 weeks of age and analyzed for adipose depots and adipose tissue cellularity. Results showed that the LCT-fed rats were significantly heavier, with larger epididymal, retroperitoneal, omental and subcutaneous fat pads than the respective pair-fed MCT rats. Also, LCT-fed rats had larger size and number of adipocytes than MCT-fed littermates. It is concluded that the type of fat in the diet, namely LCT or MCT, when fed early in life can influence the development of adipose tissue. MCT appears less lipogenic than LCT. The mechanism for the diminished adiposity of MCT-fed rats is related to extensive oxidation of MCT and its enhancement of thermogenesis leading to lessened energy efficiency.
研究了在幼年期给断奶后大鼠喂食富含长链甘油三酯（LCT）或中链甘油三酯（MCT）的饮食对脂肪组织发育的影响。除脂肪类型外，两种饮食的热量分布相似，营养成分相同。两种饮食按百分比计算的热量分布为：LCT（玉米油）/蛋白质/碳水化合物，70/18/12；MCT/玉米油/蛋白质/碳水化合物，66/4/18/12。体重差异小于5%的雄性同窝幼鼠在18 - 20日龄时随机成对喂食这两种饮食。四分之一的大鼠在10、16、22和28周龄时处死，分析脂肪库和脂肪组织细胞构成。结果显示，喂食LCT的大鼠比相应的成对喂食MCT的大鼠明显更重，附睾、腹膜后、网膜和皮下脂肪垫更大。此外，喂食LCT的大鼠的脂肪细胞大小和数量比喂食MCT的同窝幼鼠更大。得出的结论是，饮食中的脂肪类型，即LCT或MCT，在幼年期喂食时可影响脂肪组织的发育。MCT的生脂作用似乎比LCT小。喂食MCT的大鼠脂肪减少的机制与MCT的广泛氧化及其对产热的增强作用导致能量效率降低有关。
