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脂氧合酶介导的玉米对 和 感染抗性的功能研究。

Functional Study of Lipoxygenase-Mediated Resistance against and Infection in Maize.

机构信息

Department of Sustainable Crop Production, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.

C3A-Centro Agricoltura Alimenti Ambiente, Via Edmund Mach 1, 38098 San Michele all'Adige, Italy.

出版信息

Int J Mol Sci. 2022 Sep 17;23(18):10894. doi: 10.3390/ijms231810894.

DOI:10.3390/ijms231810894
PMID:36142806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9503958/
Abstract

Mycotoxin contamination of maize kernels by fungal pathogens like and is a chronic global challenge impacting food and feed security, health, and trade. Maize genes () synthetize oxylipins that play defense roles and govern host-fungal interactions. The current study investigated the involvement of in maize resistance against these two fungi. A considerable intraspecific genetic and transcript variability of the ZmLOX family was highlighted by in silico analysis comparing publicly available maize pan-genomes and pan-transcriptomes, respectively. Then, phenotyping and expression analysis of genes along with key genes involved in oxylipin biosynthesis were carried out in a maize mutant carrying a Mu transposon insertion in the gene (named UFMu) together with Tzi18, Mo17, and W22 inbred lines at 3- and 7-days post-inoculation with and . Tzi18 showed the highest resistance to the pathogens coupled with the lowest mycotoxin accumulation, while UFMu was highly susceptible to both pathogens with the most elevated mycotoxin content. inoculation determined a stronger induction of and maize genes as compared to . Additionally, oxylipin analysis revealed prevalent linoleic (18:2) peroxidation by 9-LOXs, the accumulation of 10-oxo-11-phytoenoic acid (10-OPEA), and triglyceride peroxidation only in inoculated kernels of resistant genotypes.

摘要

真菌病原体如 和 对玉米颗粒的真菌毒素污染是一个全球性的慢性挑战，影响着粮食和饲料安全、健康和贸易。玉米 基因（）合成的氧化脂类物质在防御中发挥作用，并控制宿主-真菌相互作用。本研究调查了 在玉米对这两种真菌的抗性中的作用。通过比较公开的玉米泛基因组和泛转录组的计算机分析，突出了 ZmLOX 家族的种内遗传和转录变异性很大。然后，在携带 Mu 转座子插入基因（命名为 UFMu）的玉米突变体以及 Tzi18、Mo17 和 W22 自交系中，对 基因以及参与氧化脂生物合成的关键基因进行表型和表达分析，在接种 和 后 3 天和 7 天。Tzi18 对病原体表现出最高的抗性，同时积累的真菌毒素最低，而 UFMu 对两种病原体都高度敏感，真菌毒素含量最高。与 相比， 接种决定了 和玉米 基因更强的诱导。此外，氧化脂分析显示，9-LOXs 普遍催化亚油酸（18:2）过氧化，10-氧代-11-植烯酸（10-OPEA）积累，以及仅在抗性基因型的 接种颗粒中甘油三酯过氧化。

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