Perišić Marija Majda, Vladimir Klemo, Karpov Sarah, Štorga Mario, Mostashari Ali, Khanin Raya
Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, 10000 Zagreb, Croatia.
LifeNome Inc., New York, NY 10018, USA.
J Pers Med. 2022 Aug 26;12(9):1381. doi: 10.3390/jpm12091381.
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks.
妊娠期糖尿病（GDM）是一种常见的妊娠并发症，会对母婴健康产生不利影响。多种风险因素，如体重指数（BMI）和年龄，都与妊娠期糖尿病风险增加有关。然而，在许多情况下，妊娠期糖尿病发生在没有明显风险因素的健康初产妇身上。新出现的数据表明，患妊娠期糖尿病的倾向具有遗传和环境因素。在此，我们开发了一种妊娠期糖尿病的多基因风险评分，并研究其遗传结构与基因构建的风险因素和生物标志物之间的关系。我们的结果表明，多基因风险评分可作为一种早期筛查工具，在妊娠期糖尿病发病前识别出风险较高的女性，从而开展全面监测和预防计划以降低风险。
