Ruiz-Villaverde Ricardo, Vasquez-Chinchay Fiorella, Rodriguez-Fernandez-Freire Lourdes, C Armario-Hita Jose, Pérez-Gil Amalia, Galán-Gutiérrez Manuel
Dermatology Department, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain.
Dermatology Department, Hospital Quirón Salud Sagrado Corazón, 41013 Sevilla, Spain.
Life (Basel). 2022 Sep 10;12(9):1412. doi: 10.3390/life12091412.
A fast skin clearance is the main goal to achieve in psoriasis treatment. Patients that present a fast and exceptional improvement with treatment are called super-responders (SR). There is no consensus on the definition of SR with respect to psoriasis. Included herein is a retrospective analysis of a multicenter, observational study of real clinical practices including patients with moderate-to-severe plaque PSO undergoing treatment with Guselkumab (GUS). This cross-sectional analysis includes information on patients between February 2019 to February 2022. A SR is a patient that achieved a PASI = 0 at weeks 12 and 24. Analyses have been performed "as observed" using GraphPad Prism version 8.3.0 for Windows (GraphPad Software, San Diego, CA, USA, At baseline, the PASI is significantly correlated with VAS_pruritus, BSA, and DLQI, while DLQI is significantly correlated with VAS_pruritus. Significant correlations increase in number and magnitude over the follow-up time. In relation to the univariate logistic models carried out, only three variables showed a significant association with the super-responder variable: depression, VAS_pruritus, and DLQI.SR patients, who show a faster evolution in PASI and BSA improvement than non-SRs. Based on the results obtained, it would be possible to also include DLQI and VAS_pruritus in the broader concept of the SR.
快速清除皮肤病变是银屑病治疗的主要目标。在治疗中表现出快速且显著改善的患者被称为超级应答者（SR）。关于银屑病的超级应答者定义尚无共识。本文纳入了一项多中心观察性研究的回顾性分析，该研究涉及实际临床实践中接受古塞库单抗（GUS）治疗的中度至重度斑块状银屑病患者。这项横断面分析涵盖了2019年2月至2022年2月期间患者的信息。超级应答者是指在第12周和第24周达到银屑病面积和严重程度指数（PASI）=0的患者。使用适用于Windows的GraphPad Prism 8.3.0版本（GraphPad Software，美国加利福尼亚州圣地亚哥）进行了“观察性”分析。在基线时，PASI与瘙痒视觉模拟评分（VAS_瘙痒）、体表面积（BSA）和皮肤病生活质量指数（DLQI）显著相关，而DLQI与VAS_瘙痒显著相关。在随访期间，显著相关性的数量和程度均有所增加。关于所进行的单变量逻辑模型，只有三个变量与超级应答者变量显示出显著关联：抑郁、VAS_瘙痒和DLQI。超级应答者患者在PASI和BSA改善方面的进展比非超级应答者更快。根据所得结果，也有可能将DLQI和VAS_瘙痒纳入超级应答者这一更广泛概念中。
