Lefer A M
Fed Proc. 1978 Nov;37(13):2734-40.
The widespread occurrence of circulating cardioinhibitory factors in many types of circulatory shock and in a variety of mammalian species is impressive. This review summarizes the properties of the nine best-known factors with regard to their occurrence, chemical properties, sites of origin, biological actions, and pharmacological modification. Cardioinhibitory factors appear to play a significant role in the pathogenesis of circulatory shock. There now are pharmacological means available with which to prevent the formation of such factors. With knowledge on the chemistry of cardioinhibitory factors rapidly accumulating, it is anticipated that specific antagonists to the action of these factors will become available in the near future.
循环性心抑制因子广泛存在于多种类型的循环性休克以及多种哺乳动物物种中，这一点令人印象深刻。本综述总结了九种最知名因子的特性，包括它们的存在情况、化学性质、起源部位、生物学作用以及药理学修饰。心抑制因子似乎在循环性休克的发病机制中起重要作用。目前已有预防此类因子形成的药理学方法。随着关于心抑制因子化学知识的迅速积累，预计在不久的将来会有针对这些因子作用的特异性拮抗剂。
