Medical School Department, Faculty of Medical Sciences, University College London, Gower Street, London WC1E 6BT, UK.
Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Nutrients. 2022 Sep 13;14(18):3778. doi: 10.3390/nu14183778.
Hypovitaminosis D is prevalent in epidemic proportions in many developed countries. The aim of this study is to investigate the prevalence of adequate 25-hydroxyvitamin D [25(OH)D] levels in two Mediterranean countries, Greece and Cyprus.
Data such as 25(OH)D, the month of blood sample collection, and demographic information were blindly collected from 8780 Greek and 2594 Cypriot individuals over 5 years. Comorbidities were also recorded for 839 Greek subjects. Univariate and multivariate analyses were used to examine the relationship between these variables and 25(OH)D levels.
In the samples studied, 72.7% of the Greek and 69.3% of the Cypriot population sample had inadequate levels of 25(OH)D. The mean level for the Greek subjects was 25.1 ng/mL and for Cypriots 25.8 ng/mL. For both samples, only month and gender were significantly associated with 25(OH)D levels, and the highest mean levels were recorded in September. For the recorded diseases, the lowest levels were recorded in sickle cell anaemia 13.6 ± 10.2 ng/mL, autoimmune diseases 13.0 ± 8.4 ng/mL, and cancer 22.6 ± 9.5 ng/mL.
The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries.
在许多发达国家，维生素 D 缺乏症普遍流行。本研究旨在调查两个地中海国家（希腊和塞浦路斯）中 25-羟维生素 D [25(OH)D] 充足水平的流行情况。
5 年来，我们从 8780 名希腊人和 2594 名塞浦路斯人身上收集了 25(OH)D、采血月份和人口统计学信息等数据，还记录了 839 名希腊患者的合并症。我们使用单变量和多变量分析来研究这些变量与 25(OH)D 水平之间的关系。
在所研究的样本中，72.7%的希腊人和 69.3%的塞浦路斯人口样本 25(OH)D 水平不足。希腊受试者的平均水平为 25.1ng/ml，塞浦路斯人为 25.8ng/ml。对于这两个样本，只有月份和性别与 25(OH)D 水平显著相关，9 月记录到的平均水平最高。对于所记录的疾病，镰状细胞性贫血的水平最低，为 13.6±10.2ng/ml，自身免疫性疾病为 13.0±8.4ng/ml，癌症为 22.6±9.5ng/ml。
在这两个地中海国家，维生素 D 缺乏症的流行率都出人意料地高。
