Department of Health Sciences, Federal University of Rio Grande Do Norte, Av. General Cordeiro de Farias, S/N - Petrópolis, Natal, RN, 59012-570, Brazil.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.
Sci Rep. 2020 Jul 20;10(1):11943. doi: 10.1038/s41598-020-69128-2.
Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRNA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. Our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications.
维生素 D 补充剂被广泛应用。然而，对于这种补充剂的使用和剂量尚未达成共识，现有的建议是基于该营养素对骨骼有益的研究得出的。此外，个体遗传学可能会影响补充的反应，因此，涉及同卵双胞胎的研究旨在减少表型反应的这些差异。本随机对照研究的目的是研究维生素 D 补充剂对身体成分和维生素 D 受体 (VDR) mRNA 表达的影响。通过在 90 对健康的成年同卵双胞胎（男性或女性对）中补充浓度为 2000 IU 的胆钙化醇进行干预，持续 2 个月。研究结果表明，血清维生素 D 浓度增加了 65%，VDR 基因表达增加了 60 倍（p=0.001）。观察到身体脂肪和瘦体重等身体成分参数的变化。我们的结果表明，血清维生素 D 浓度的增加可能具有潜在的治疗意义。
