Center for Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Nutrients. 2022 Sep 18;14(18):3867. doi: 10.3390/nu14183867.
Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models.
卵巢癌是女性中最致命的癌症之一，因为其异质性和通常晚期诊断。目前的一线治疗方法——减瘤手术和强化化疗——会引起使人衰弱的副作用。因此，人们迫切需要找到新的、有效的、副作用更少的治疗方法，或辅助治疗方法，以减少化疗药物的必要剂量。维生素 D 是血清钙和磷稳态的主要调节剂之一，但它也具有抗癌作用。它诱导细胞分化和凋亡，降低癌细胞的增殖和转移潜力。然而，对抗癌症有效的剂量会导致高钙血症。因此，已经开发并测试了合成的、钙含量较低的类似物，以评估其抗癌作用。维生素 D 的抗癌作用在结直肠癌、乳腺癌和前列腺癌中得到了很好的理解，而在卵巢癌中则进行了较少的研究。因此，在这篇综述中，我们总结了维生素 D 及其类似物在卵巢癌模型中的体外和体内研究。
