Graham D I, Lawrence A E, Adams J H, Doyle D, McLellan D R
Neuropathol Appl Neurobiol. 1987 May-Jun;13(3):209-17. doi: 10.1111/j.1365-2990.1987.tb00184.x.
A comprehensive neuropathological analysis was undertaken on 434 patients who died as a result of a non-missile head injury in order to determine the frequency and extent of brain damage secondary to high intracranial pressure (ICP) in head injury. Using the criterion of pressure necrosis in the parahippocampal gyrus as evidence of high ICP due to a supratentorial expanding lesion, it was established that the ICP had been high in 324 cases. In 42 of these there was no other brain damage attributable to a high ICP. There was evidence of secondary brain stem damage in 221 cases and in 44 of these the damage could be seen only microscopically. In 54 cases there was a contralateral peduncular lesion. Other abnormalities were infarction in the territories of various arteries and in the anterior lobe of the pituitary. There was a supracallosal hernia in 80 cases and haemorrhage in the oculomotor nerves in 48 cases. These results further emphasise the frequency and range of brain damage due to secondary vascular factors brought about by high ICP in a patient who has sustained a head injury.
对434例因非火器性头部损伤死亡的患者进行了全面的神经病理学分析，以确定头部损伤继发于高颅内压（ICP）时脑损伤的频率和程度。以海马旁回的压力性坏死作为幕上占位性病变导致高ICP的证据，确定324例患者的ICP曾处于高水平。其中42例没有其他可归因于高ICP的脑损伤。有221例存在继发性脑干损伤，其中44例只能在显微镜下观察到损伤。54例有对侧脑桥病变。其他异常包括不同动脉供血区域及垂体前叶的梗死。80例有胼胝体上疝，48例动眼神经有出血。这些结果进一步强调了头部受伤患者因高ICP导致的继发性血管因素所致脑损伤的频率和范围。
