针对新发和被忽视传染病的疫苗：概述
Vaccines against Emerging and Neglected Infectious Diseases: An Overview.
作者信息
Vuitika Larissa, Prates-Syed Wasim A, Silva Jaqueline Dinis Queiros, Crema Karin P, Côrtes Nelson, Lira Aline, Lima Julia Beatriz Menuci, Camara Niels Olsen Saraiva, Schimke Lena F, Cabral-Marques Otavio, Sadraeian Mohammad, Chaves Lorena C S, Cabral-Miranda Gustavo
机构信息
Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo (ICB-IV/USP), São Paulo 05508-000, SP, Brazil.
Institute of Research and Education in Child Health (PENSI), São Paulo 01228-200, SP, Brazil.
出版信息
Vaccines (Basel). 2022 Aug 25;10(9):1385. doi: 10.3390/vaccines10091385.
Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and vaccines are the best prophylactic tool against them. Along with NTDs, emerging and reemerging infectious diseases also threaten global public health, as they can unpredictably result in pandemics. The recent advances in vaccinology allowed the development and licensing of new vaccine platforms that can target and prevent these diseases. In this work, we discuss the advances in vaccinology and some of the difficulties found in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases, including HIV, Dengue, Ebola, Chagas disease, malaria, leishmaniasis, zika, and chikungunya.
被忽视的热带病（NTDs）是一类在热带和亚热带地区高度流行的疾病，与贫困和边缘化人群密切相关。传染病每年影响超过16亿人，而疫苗是预防这些疾病的最佳工具。除了被忽视的热带病，新出现和再次出现的传染病也威胁着全球公共卫生，因为它们可能不可预测地导致大流行。疫苗学的最新进展使得能够针对并预防这些疾病的新疫苗平台得以开发和获批。在这项工作中，我们讨论了疫苗学的进展以及在针对选定的被忽视的热带病和新出现及再次出现的传染病（包括艾滋病毒、登革热、埃博拉、恰加斯病、疟疾、利什曼病、寨卡和基孔肯雅热）的疫苗研发过程中发现的一些困难。
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