HIV-1疫苗的现状
Current Status of HIV-1 Vaccines.
作者信息
Hargrave Anna, Mustafa Abu Salim, Hanif Asma, Tunio Javed H, Hanif Shumaila Nida M
机构信息
Department of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, KY 41501, USA.
Department of Microbiology, College of Medicine, Kuwait University, Kuwait City 12037, Kuwait.
出版信息
Vaccines (Basel). 2021 Sep 16;9(9):1026. doi: 10.3390/vaccines9091026.
Abstract
HIV-1 infection and its progression to AIDS remains a significant global health challenge, particularly for low-income countries. Developing a vaccine to prevent HIV-1 infections has proven to be immensely challenging with complex biological acquisition and infection, unforeseen clinical trial disappointments, and funding issues. This paper discusses important landmarks of progress in HIV-1 vaccine development, various vaccine strategies, and clinical trials.
摘要
人类免疫缺陷病毒1型（HIV-1）感染及其向获得性免疫缺陷综合征（AIDS）的进展仍然是一项重大的全球卫生挑战，尤其是对低收入国家而言。事实证明，开发一种预防HIV-1感染的疫苗极具挑战性，原因包括复杂的生物学感染机制、临床试验中意外的挫折以及资金问题。本文讨论了HIV-1疫苗开发进程中的重要里程碑、各种疫苗策略以及临床试验情况。
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2
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