癫痫持续状态治疗继发钠通道毒性所致奇异型宽QRS波心动过速：病例报告
Bizarre wide complex tachycardia caused by sodium channel toxicity secondary to the management of status epilepticus: Case report.
作者信息
AlMutairi Ghazi T
机构信息
Department of Medicine, Unaizah College of Medicine and Medical Science, Qassim University, Saudi Arabia.
出版信息
Ann Med Surg (Lond). 2022 Sep 2;81:104558. doi: 10.1016/j.amsu.2022.104558. eCollection 2022 Sep.
INTRODUCTION AND IMPORTANCE
Antiepileptic drugs therapy are associated with myriad adverse effects. Some of antiepileptic drugs (AEDs) inhibit sodium channels that may cause dysrhythmia and hemodynamic instability if administered in too high dose.
CASE PRESENTATION
We describe a patient with wide complex tachycardia likely secondary to medical management of status epilepticus specifically secondary to sodium channels blockade that successfully managed with supportive care and one session of hemodialysis.
CONCLUSION
In this case report, we discuss the successful management of the first reported combination of AEDs (Phenytoin and lacosamide) toxicity using supportive care and extracorporeal removal.
引言与重要性
抗癫痫药物治疗会带来众多不良反应。一些抗癫痫药物（AEDs）会抑制钠通道，如果剂量过高，可能会导致心律失常和血流动力学不稳定。
病例介绍
我们描述了一名患有宽QRS波心动过速的患者，可能继发于癫痫持续状态的药物治疗，特别是继发于钠通道阻滞，通过支持治疗和一次血液透析成功治愈。
结论
在本病例报告中，我们讨论了首例报道的AEDs（苯妥英和拉科酰胺）联合中毒，通过支持治疗和体外清除成功处理的情况。
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