Timur Burcu, Aldemir Oya, İnan Nihat, Kaplanoğlu İskender, Dilbaz Serdar
University of Health Sciences Turkey, Etlik Zübeyde Hanım Training and Research Hospital, IVF Center, Clinic of Obstetrics and Gynecology, Ankara, Turkey.
Ordu University Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ordu, Turkey.
Turk J Obstet Gynecol. 2022 Sep 23;19(3):207-214. doi: 10.4274/tjod.galenos.2022.05760.
Ceramide (CER) is a bioactive component of the mitochondrial membrane. In this study, we will investigate the clinical importance of serum CER (sCER) and follicular fluid CER (ffCER) levels in the lipid synthesis pathway and their effect on poor oocyte quality and in vitro fertilization (IVF) outcome.
This cross-sectional, case-control study was conducted in the IVF unit of a maternity hospital in the capital of Turkey, Ankara. A total of 88 women undergoing their first IVF cycle were included in this study patients were divided into 2 groups according to current diagnostic criteria for their ovarian reserves. Baseline sCER levels, and ffCER concentrations retrieved on the oocyte pickup day were measured.
The mean age, body mass index, and infertility duration of the patients was similar between the groups (all p>0.05). There was also no significant difference in the clinical pregnancy rates (38.6% vs. 47.7%, p=0.127). sCER (15.6±6.5 vs. 23.5±8.9) and ffCER (82.5±34.3 vs. 116.4±46.5) levels were statistically significantly lower in the low ovarian reserve (LOR) group (both p<0.001). The performed receiver operating characteristic curve analysis revealed that sCER and ffCER levels could predict both LOR and pregnancy.
This is the first study evaluating the sCER and ffCER levels of patients undergoing IVF treatment. CER may be used as an ovarian reserve markers and a biomarker capable of predicting IVF outcomes.
神经酰胺（CER）是线粒体膜的一种生物活性成分。在本研究中，我们将探讨脂质合成途径中血清CER（sCER）和卵泡液CER（ffCER）水平的临床重要性，以及它们对卵母细胞质量差和体外受精（IVF）结局的影响。
本横断面病例对照研究在土耳其首都安卡拉一家妇产医院的体外受精科进行。本研究共纳入88名接受首次IVF周期治疗的女性，根据目前的卵巢储备诊断标准将患者分为2组。测量基线sCER水平以及取卵日采集的ffCER浓度。
两组患者的平均年龄、体重指数和不孕持续时间相似（均p>0.05）。临床妊娠率也无显著差异（38.6%对47.7%，p=0.127）。低卵巢储备（LOR）组的sCER（15.6±6.5对23.5±8.9）和ffCER（82.5±34.3对116.4±46.5）水平在统计学上显著较低（均p<0.001）。所进行的受试者工作特征曲线分析显示，sCER和ffCER水平可预测LOR和妊娠情况。
这是第一项评估接受IVF治疗患者的sCER和ffCER水平的研究。CER可用作卵巢储备标志物和能够预测IVF结局的生物标志物。
