PROFITH 'PRO-moting FITness and Health Through Physical Activity' Research Group, Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sports Science, University of Granada, Granada, Spain.
Turku PET Centre, University of Turku, Turku, Finland.
Eur J Endocrinol. 2022 Jun 1;187(1):171-183. doi: 10.1530/EJE-22-0130. Print 2022 Jul 1.
Brown adipose tissue (BAT) is important in the maintenance of cardiometabolic health in rodents. Recent reports appear to suggest the same in humans, although if this is true remains elusive partly because of the methodological bias that affected previous research. This cross-sectional work reports the relationships of cold-induced BAT volume, activity (peak standardized uptake, SUVpeak), and mean radiodensity (an inverse proxy of the triacylglycerols content) with the cardiometabolic and inflammatory profile of 131 young adults, and how these relationships are influenced by sex and body weight.
This is a cross-sectional study.
Subjects underwent personalized cold exposure for 2 h to activate BAT, followed by static 18F-fluorodeoxyglucose PET-CT scanning to determine BAT variables. Information on cardiometabolic risk (CMR) and inflammatory markers was gathered, and a CMR score and fatty liver index (FLI) were calculated.
In men, BAT volume was positively related to homocysteine and liver damage markers concentrations (independently of BMI and seasonality) and the FLI (all P ≤ 0.05). In men, BAT mean radiodensity was negatively related to the glucose and insulin concentrations, alanine aminotransferase activity, insulin resistance, total cholesterol/HDL-C, LDL-C/HDL-C, the CMR score, and the FLI (all P ≤ 0.02). In women, it was only negatively related to the FLI (P < 0.001). These associations were driven by the results for the overweight and obese subjects. No relationship was seen between BAT and inflammatory markers (P > 0.05).
A larger BAT volume and a lower BAT mean radiodensity are related to a higher CMR, especially in young men, which may support that BAT acts as a compensatory organ in states of metabolic disruption.
棕色脂肪组织（BAT）在维持啮齿动物的心脏代谢健康方面很重要。最近的报告似乎表明人类也是如此，尽管这是否属实仍然难以捉摸，部分原因是先前研究中的方法学偏见。这项横断面研究报告了冷诱导 BAT 体积、活性（峰值标准化摄取量，SUVpeak）和平均放射性密度（三酰甘油含量的逆代理）与 131 名年轻成年人的心脏代谢和炎症特征之间的关系，以及这些关系如何受到性别和体重的影响。
这是一项横断面研究。
受试者接受个性化的 2 小时冷暴露以激活 BAT，然后进行静态 18F-氟脱氧葡萄糖 PET-CT 扫描以确定 BAT 变量。收集心脏代谢风险（CMR）和炎症标志物信息，并计算 CMR 评分和脂肪肝指数（FLI）。
在男性中，BAT 体积与同型半胱氨酸和肝损伤标志物浓度（独立于 BMI 和季节性）和 FLI（均 P≤0.05）呈正相关。在男性中，BAT 平均放射性密度与血糖和胰岛素浓度、丙氨酸氨基转移酶活性、胰岛素抵抗、总胆固醇/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇、CMR 评分和 FLI（均 P≤0.02）呈负相关。在女性中，它仅与 FLI 呈负相关（P<0.001）。这些关联是由超重和肥胖受试者的结果驱动的。BAT 与炎症标志物之间没有关系（P>0.05）。
更大的 BAT 体积和更低的 BAT 平均放射性密度与更高的 CMR 相关，尤其是在年轻男性中，这可能支持 BAT 在代谢紊乱状态下作为代偿性器官的作用。
