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超高度反光电膜在糖尿病黄斑水肿的视网膜界面：一个发现超高度分辨率光学相干断层扫描。

Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography.

机构信息

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Department of Ophthalmology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.

出版信息

Transl Vis Sci Technol. 2022 Sep 1;11(9):21. doi: 10.1167/tvst.11.9.21.

DOI:10.1167/tvst.11.9.21
PMID:36149646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9520517/
Abstract

PURPOSE

Detecting subtle vitreoretinal interface (VRI) findings, such as a posterior hyaloid membrane, is difficult with conventional retinal imaging. We compared ultra-high-resolution spectral domain optical coherence tomography (UHR-SD-OCT) with standard-resolution OCT (SD-OCT) for the imaging of VRI abnormalities in diabetic retinopathy (DR).

METHODS

This prospective cross-sectional study included 113 consecutive patients (91 patients with diabetes and 22 healthy controls). The VRI was evaluated, and the results were compared between the conventional SD-OCT and UHR-SD-OCT images. VRI findings were also investigated before and after internal limiting membrane peeling during vitrectomy for proliferative DR.

RESULTS

A total of 159 eyes (87.4%) of 91 patients with diabetes were analyzed. UHR-SD-OCT could detect a hyperreflective layer at the VRI, in which en face OCT showed a membrane-like structure, termed the hyperreflective membrane (HRMe). The preoperative HRMe could not be detected in all patients with proliferative DR who underwent internal limiting membrane peeling during vitrectomy. Although the HRMe did not correlate with the DR stage, eyes with diabetic macular edema (DME) (64.5%) showed a significant HRMe with UHR-SD-OCT more frequently than those without DME (35.8%) (P = 0.005).

CONCLUSIONS

UHR-SD-OCT can detect the HRMe at the VRI in DR eyes, particularly in eyes with DME. The HRMe may present a thickened posterior hyaloid membrane that contributes to DME development.

TRANSLATIONAL RELEVANCE

UHR-SD-OCT detects slight changes in the VRI in DR eyes. In the future, it may help to elucidate the mechanism of DME formation.

摘要

目的

用传统的视网膜成像技术很难发现细微的玻璃体视网膜界面 (VRI) 病变，如后玻璃体膜。我们比较了超高分辨率谱域光学相干断层扫描 (UHR-SD-OCT) 与标准分辨率 OCT (SD-OCT) 在糖尿病视网膜病变 (DR) 中 VRI 异常成像的效果。

方法

这项前瞻性的横断面研究纳入了 113 例连续患者（91 例糖尿病患者和 22 例健康对照者）。评估了 VRI，并比较了传统的 SD-OCT 和 UHR-SD-OCT 图像的结果。还研究了增生性 DR 玻璃体切割术中内界膜剥离前后的 VRI 病变。

结果

分析了 91 例糖尿病患者的 159 只眼（87.4%）。UHR-SD-OCT 可在 VRI 处检测到一高反射层，在该处 OCT 横断面图像上可见一膜状结构，称为高反射膜（HRMe）。所有行玻璃体切割术内界膜剥离的增生性 DR 患者术前均无法检测到 HRMe。尽管 HRMe 与 DR 分期无关，但合并糖尿病黄斑水肿 (DME)（64.5%）的眼较无 DME（35.8%）更常出现 UHR-SD-OCT 可见的显著 HRMe（P=0.005）。

结论

UHR-SD-OCT 可在 DR 眼中检测到 VRI 处的 HRMe，尤其是在合并 DME 的眼中。HRMe 可能代表了后玻璃体膜增厚，有助于 DME 的发生。

翻译

张佳妮

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/471cea424f40/tvst-11-9-21-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/d5d6fff14d83/tvst-11-9-21-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/3ae3df310241/tvst-11-9-21-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/471cea424f40/tvst-11-9-21-f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/d5d6fff14d83/tvst-11-9-21-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/3ae3df310241/tvst-11-9-21-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb5/9520517/471cea424f40/tvst-11-9-21-f003.jpg

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