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α-蒎烯和α-水芹烯的伤口愈合活性。

Wound Healing Activity of α-Pinene and α-Phellandrene.

作者信息

Salas-Oropeza Judith, Jimenez-Estrada Manuel, Perez-Torres Armando, Castell-Rodriguez Andres Eliu, Becerril-Millan Rodolfo, Rodriguez-Monroy Marco Aurelio, Jarquin-Yañez Katia, Canales-Martinez Maria Margarita

机构信息

Laboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores Iztacala, UNAM, 54108 Tlalnepantla, Mexico.

Instituto de Quimica, UNAM, Circuito Exterior, Ciudad Universitaria, 02860 D.F., Mexico.

出版信息

Molecules. 2021 Apr 24;26(9):2488. doi: 10.3390/molecules26092488.

DOI:10.3390/molecules26092488
PMID:33923276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8123182/
Abstract

is used in Mexican folk medicine to treat wounds on the skin. Recently, it was shown that the essential oil (EO) of has wound healing activity, accelerating cutaneous wound closure and generating scars with good tensile strength. α-pinene (PIN) and α-phellandrene (FEL) are terpenes that have been found in this EO, and it has been shown in different studies that both have anti-inflammatory activity. The aim of this study was to determine the wound healing activity of these two terpenes. The results of in vitro tests demonstrate that PIN and FEL are not cytotoxic at low concentrations and that they do not stimulate fibroblast cell proliferation. In vivo tests showed that the terpenes produce stress-resistant scars and accelerate wound contraction, due to collagen deposition from the early stages, in wounds treated with both terpenes. Therefore, we conclude that both α-pinene and α-phellandrene promote the healing process; this confirms the healing activity of the EO of , since having these terpenes as part of its chemical composition explains part of its demonstrated activity.

摘要

在墨西哥民间医学中用于治疗皮肤伤口。最近的研究表明，[植物名称]的精油（EO）具有伤口愈合活性，可加速皮肤伤口闭合并产生具有良好抗张强度的疤痕。α-蒎烯（PIN）和α-水芹烯（FEL）是在该精油中发现的萜类化合物，并且在不同研究中已表明二者均具有抗炎活性。本研究的目的是确定这两种萜类化合物的伤口愈合活性。体外试验结果表明，PIN和FEL在低浓度下无细胞毒性，且不刺激成纤维细胞增殖。体内试验表明，在用这两种萜类化合物处理的伤口中，由于早期阶段的胶原蛋白沉积，这些萜类化合物会产生抗应激疤痕并加速伤口收缩。因此，我们得出结论，α-蒎烯和α-水芹烯均能促进愈合过程；这证实了[植物名称]精油的愈合活性，因为其化学成分中含有这些萜类化合物解释了其部分已证实的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/e9d6593dbc73/molecules-26-02488-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/effca140afe9/molecules-26-02488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/6ad8f1e86db8/molecules-26-02488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/d31c6afd88de/molecules-26-02488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/a9622fdc3ba9/molecules-26-02488-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/2fed84ebb399/molecules-26-02488-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/2946be8cf0b3/molecules-26-02488-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/1b7e19fc9097/molecules-26-02488-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/e0aa17859c29/molecules-26-02488-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/e9d6593dbc73/molecules-26-02488-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/effca140afe9/molecules-26-02488-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/6ad8f1e86db8/molecules-26-02488-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/d31c6afd88de/molecules-26-02488-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/a9622fdc3ba9/molecules-26-02488-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/2fed84ebb399/molecules-26-02488-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/2946be8cf0b3/molecules-26-02488-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/1b7e19fc9097/molecules-26-02488-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/e0aa17859c29/molecules-26-02488-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/8123182/e9d6593dbc73/molecules-26-02488-g009.jpg

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