Edén C S, Hansson H A
Infect Immun. 1978 Jul;21(1):229-37. doi: 10.1128/iai.21.1.229-237.1978.
Presence of pili of fimbriae on Escherichia coli bacteria isolated from the urine of patients with urinary tract infection was related to the ability of the bacteria to attach to human uroepithelial cells. Piliated E. coli strains agglutinated guinea pig erythrocytes. D-Mannose and alpha-methyl-D-mannopyranoside inhibited this agglutination with all but one of the 12 strains tested. D-Mannose, D-galactose, alpha-methyl-D-mannopyranoside, and L-fucose did not afect attachment of piliated strains to uroepithelial cells. Heating as well as washing of piliated strains caused a parallel decrease of piliation and adhesive ability. Growth in glucose-enriched medium increased capsule formation but decreased piliation and adhesion. Capsulated strains retained their adhesive ability provided that pili extended outside the capsule.
从尿路感染患者尿液中分离出的大肠杆菌上菌毛的存在与细菌附着于人尿道上皮细胞的能力有关。有菌毛的大肠杆菌菌株能凝集豚鼠红细胞。在所测试的12株菌株中，除1株外，D-甘露糖和α-甲基-D-甘露吡喃糖苷均能抑制这种凝集。D-甘露糖、D-半乳糖、α-甲基-D-甘露吡喃糖苷和L-岩藻糖不影响有菌毛菌株与尿道上皮细胞的附着。对有菌毛菌株进行加热和洗涤会导致菌毛形成和黏附能力同时下降。在富含葡萄糖的培养基中生长会增加荚膜形成，但会减少菌毛形成和黏附。只要菌毛延伸到荚膜外，有荚膜的菌株就会保留其黏附能力。
