Wager-Srdar S A, Gannon M, Levine A S
Physiol Behav. 1987;40(1):25-8. doi: 10.1016/0031-9384(87)90180-6.
Cholecystokinin (CCK) suppresses food intake in a number of animal models, but appears to be less effective in females [5,23]. We studied the effect of CCK on food intake in female rats on each day of the estrous cycle. In addition, we evaluated the effect of sex hormones on food intake in intact and castrate male rats which had been injected daily with oil or testosterone propionate + oil and ovariectomized female rats injected daily with oil, estradiol, progesterone or estradiol + progesterone. Food intake in intact, castrate and castrate + testosterone replaced male rats was decreased by CCK (5, 10 and 20 micrograms/kg) IP (p less than 0.05). Food intake was decreased by CCK (20 micrograms/kg) only during diestrous and metestrus in cycling female rats. During metestrus, a period of low estradiol in the presence of progesterone, food intake was also suppressed by CCK (5 and 10 micrograms/kg). CCK failed to decrease food intake in ovariectomized females receiving oil, estradiol and estradiol + progesterone. However, animals receiving progesterone alone responded to the high dose of CCK (20 micrograms/kg). Our data suggest that the effect of CCK on food intake in female rats may be dependent on the presence of progesterone. The lack of sensitivity to CCK during proestrus and estrus suggests that estradiol may be modulating the "permissive" action of progesterone on CCK's satiety effect.
胆囊收缩素（CCK）在多种动物模型中可抑制食物摄入，但在雌性动物中似乎效果较差[5,23]。我们研究了CCK在雌性大鼠发情周期的每一天对食物摄入的影响。此外，我们评估了性激素对完整和去势雄性大鼠食物摄入的影响，这些雄性大鼠每天注射油剂或丙酸睾酮+油剂，以及对去卵巢雌性大鼠食物摄入的影响，这些雌性大鼠每天注射油剂、雌二醇、孕酮或雌二醇+孕酮。腹腔注射CCK（5、10和20微克/千克）可使完整、去势和去势+睾酮替代的雄性大鼠的食物摄入量减少（P<0.05）。在发情周期的雌性大鼠中，仅在动情后期和间情期，CCK（20微克/千克）可使食物摄入量减少。在间情期，即孕酮存在下雌二醇水平较低的时期，CCK（5和10微克/千克）也可抑制食物摄入。CCK未能使接受油剂、雌二醇和雌二醇+孕酮的去卵巢雌性大鼠的食物摄入量减少。然而，单独接受孕酮的动物对高剂量CCK（20微克/千克）有反应。我们的数据表明，CCK对雌性大鼠食物摄入的影响可能取决于孕酮的存在。在发情前期和发情期对CCK缺乏敏感性表明，雌二醇可能在调节孕酮对CCK饱腹感作用的“允许”作用。
