Sanne Ahles, Department of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 6200 MD Maastricht, The Netherlands;
J Nutr Health Aging. 2022;26(9):839-846. doi: 10.1007/s12603-022-1834-4.
This study investigates whether a citrus and pomegranate complex (CPC) improves physical fitness, mental well-being, and blood biomarkers for oxidative stress and endothelial function in healthy elderly.
A randomized placebo-controlled cross-over trial.
The study included 36 healthy elderly aged 60-75 years old.
Participants received four weeks of CPC supplementation and performed the handgrip strength and senior fitness test. Quality of life (QOL) was assessed and blood samples were analyzed for oxidative stress and endothelial function markers.
After four weeks of CPC supplementation, handgrip strength significantly improved (p=0.019), compared to placebo. Moreover, the thinking, memory, learning, and concentration facets were improved (p=0.042), compared to placebo, and plasma malondialdehyde decreased, compared to placebo (p=0.033). The intervention did not affect senior fitness and the other QOL domains and blood parameters.
Four weeks of daily CPC supplementation significantly improves handgrip strength and self-evaluated measures of psychological function in healthy older adults. Further research should focus on mechanisms associated with physical performance.
本研究旨在探讨柑橘和石榴复合物（CPC）是否能改善健康老年人的身体机能、心理健康、氧化应激和内皮功能的血液生物标志物。
一项随机安慰剂对照交叉试验。
研究纳入了 36 名年龄在 60-75 岁之间的健康老年人。
参与者接受了四周的 CPC 补充，并进行了握力和老年人体能测试。生活质量（QOL）进行了评估，血液样本用于分析氧化应激和内皮功能标志物。
与安慰剂相比，CPC 补充四周后握力显著提高（p=0.019）。此外，与安慰剂相比，思维、记忆、学习和注意力方面得到改善（p=0.042），血浆丙二醛水平下降（p=0.033）。干预措施对老年人体能和其他 QOL 领域以及血液参数没有影响。
四周的 CPC 补充可显著改善健康老年人的握力和自我评估的心理功能。进一步的研究应关注与身体表现相关的机制。
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