BioActor BV, Gaetano Martinolaan 85, 6229 GS, Maastricht, The Netherlands.
Division Gastroenterology-Hepatology, Department of Internal Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
J Int Soc Sports Nutr. 2021 Jan 6;18(1):2. doi: 10.1186/s12970-020-00399-w.
Nutritional supplementation is commonly used by athletes to improve their exercise performance. Previous studies demonstrated that citrus flavonoid extract (CFE) supplementation may be an effective strategy to improve exercise performance in male athletes. Yet, no conclusive research has been performed to investigate the effect of chronic CFE supplementation on high-intensity exercise performance under anaerobic conditions. Therefore, the aim of the study was to assess whether CFE supplementation in daily dosages of 400 and 500 mg for a period of 4 and 8 weeks improves anaerobic exercise capacity.
A randomized, double-blind, placebo controlled, parallel clinical study was conducted in 92 moderately trained healthy men and women. Subjects were randomized to receive 400 mg of CFE (n = 30), 500 mg of CFE (n = 31) or placebo (n = 31) daily, for 8 consecutive weeks. The Wingate anaerobic test was used to assess anaerobic exercise capacity and power output at baseline, after 4 weeks and after 8 weeks.
After 4 weeks supplementation, average power output significantly increased in the 400 mg group (Estimated difference [ED] = 38.2 W [18.0, 58.3]; p < 0.001; effect size [ES] = 0.27) and in the 500 mg group (ED = 21.2 W [0.91, 41.4]; p = 0.041; ES = 0.15) compared to placebo. The 5 s peak power output was also increased in the 400 mg group (ED = 53.6 [9.96, 97.2]; p = 0.017; ES = 0.25) after 4 weeks compared to placebo. After 8 weeks of supplementation, average power output was significantly improved in the group receiving 400 mg of CFE (ED = 31.6 [8.33, 54.8]; p = 0.008; ES = 0.22) compared to placebo.
These results demonstrate that CFE supplementation improved anaerobic capacity and peak power during high intensity exercise in moderately trained individuals. Further research is needed to identify the underlying mechanisms that are affected by CFE supplementation.
ClinicalTrials.gov ( NCT03044444 ). Registered 7 February 2017.
营养补充剂常用于运动员以提高运动表现。先前的研究表明，柑橘类黄酮提取物（CFE）补充可能是提高男性运动员运动表现的有效策略。然而，尚无确凿的研究来调查慢性 CFE 补充在厌氧条件下高强度运动表现的影响。因此，本研究旨在评估每日补充 400 和 500 毫克 CFE 4 至 8 周是否可以提高厌氧运动能力。
在 92 名中度训练的健康男性和女性中进行了一项随机、双盲、安慰剂对照、平行临床试验。受试者随机接受每日 400 毫克 CFE（n=30）、500 毫克 CFE（n=31）或安慰剂（n=31），连续 8 周。使用瓦格纳无氧测试在基线、4 周后和 8 周后评估无氧运动能力和功率输出。
补充 4 周后，400 毫克组的平均功率输出显著增加（估计差值[ED]=38.2W[18.0，58.3]；p<0.001；效应大小[ES]=0.27）和 500 毫克组（ED=21.2W[0.91，41.4]；p=0.041；ES=0.15）与安慰剂相比。400 毫克组的 5 秒峰值功率输出也在 4 周后增加（ED=53.6[9.96，97.2]；p=0.017；ES=0.25）与安慰剂相比。补充 8 周后，接受 400 毫克 CFE 组的平均功率输出显著提高（ED=31.6[8.33，54.8]；p=0.008；ES=0.22）与安慰剂相比。
这些结果表明，CFE 补充剂可改善中度训练个体高强度运动时的厌氧能力和峰值功率。需要进一步研究以确定受 CFE 补充影响的潜在机制。
ClinicalTrials.gov（NCT03044444）。2017 年 2 月 7 日注册。
