• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunotherapy of a guinea pig hepatoma with mycobacterial vaccines: comparison of BCG cell walls and cell wall skeletons.用分枝杆菌疫苗对豚鼠肝癌进行免疫治疗：卡介苗细胞壁与细胞壁骨架的比较
Infect Immun. 1978 Sep;21(3):1029-32. doi: 10.1128/iai.21.3.1029-1032.1978.
2
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.用移植性肝癌对豚鼠进行免疫治疗：瘤内注射灭活卡介苗细胞与卡介苗细胞壁的比较
Infect Immun. 1979 Sep;25(3):1087-9. doi: 10.1128/iai.25.3.1087-1089.1979.
3
Immunotherapy of experimental cancer by intralesional injection of emulsified nonliving mycobacteria: comparison of Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis.通过瘤内注射乳化的非活性分枝杆菌进行实验性癌症免疫治疗：牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌的比较
Infect Immun. 1980 Jun;28(3):887-92. doi: 10.1128/iai.28.3.887-892.1980.
4
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally injected emulsions containing heat-killed Nocardia rubra, Mycobacterium bovis (BCG) and Mycobacterium phlei.用移植性肝癌对豚鼠进行免疫治疗：对瘤内注射含有热灭活红色诺卡氏菌、牛型分枝杆菌（卡介苗）和草分枝杆菌的乳剂的比较。
Oncology. 1982;39(5):314-8. doi: 10.1159/000225659.
5
Immunotherapy of guinea pigs with dermal and visceral tumor implants: comparison of living and nonliving BCG.用皮肤和内脏肿瘤植入物对豚鼠进行免疫治疗：活卡介苗与灭活卡介苗的比较
Infect Immun. 1979 May;24(2):565-66. doi: 10.1128/iai.24.2.565-566.1979.
6
Safety and efficacy of living BCG or BCG cell walls (CW) in the treatment of guinea pig hepatoma.活卡介苗或卡介苗细胞壁（CW）治疗豚鼠肝癌的安全性和有效性。
Cancer. 1979 Feb;43(2):484-91. doi: 10.1002/1097-0142(197902)43:2<484::aid-cncr2820430213>3.0.co;2-j.
7
Cutaneous granulomatous response to BCG cell walls with reference to cancer immunotherapy.卡介苗细胞壁的皮肤肉芽肿反应与癌症免疫治疗的关系
Infect Immun. 1976 Feb;13(2):543-53. doi: 10.1128/iai.13.2.543-553.1976.
8
Immunotherapy of guinea pig cancer with BCG.用卡介苗对豚鼠癌症进行免疫治疗。
Johns Hopkins Med J Suppl. 1974;3:121-30.
9
Synergistic activity of components of mycobacteria and mutant Salmonella in causing regression of line-10 tumors in guinea pigs.分枝杆菌成分与突变沙门氏菌在使豚鼠10号线肿瘤消退方面的协同活性。
Cancer Res. 1979 May;39(5):1766-71.
10
Induced sensitization to nickel in guinea pigs immunized with mycobacteria by injection of purified protein derivative with nickel.通过注射含镍的纯化蛋白衍生物，使经分枝杆菌免疫的豚鼠对镍产生致敏作用。
New Microbiol. 2003 Jan;26(1):101-8.

引用本文的文献

1
Proteomic networks associated with tumor-educated macrophage polarization and cytotoxicity potentiated by heat-killed tuberculosis.与肿瘤诱导的巨噬细胞极化以及热灭活结核杆菌增强的细胞毒性相关的蛋白质组学网络
Sci Rep. 2022 Apr 27;12(1):6881. doi: 10.1038/s41598-022-10463-x.

本文引用的文献

1
Mycobacterial cell wall components in tumor suppression and regression.
Natl Cancer Inst Monogr. 1973 Dec;39:115-9.
2
Biologically active components from mycobacterial cell walls. I. Isolation and composition of cell wall skeleton and component P3.分枝杆菌细胞壁的生物活性成分。I. 细胞壁骨架和成分P3的分离与组成
J Natl Cancer Inst. 1974 Jan;52(1):95-101. doi: 10.1093/jnci/52.1.95.
3
Immunotherapy of cancer: regression of established intradermal tumors after intralesional injection of mycobacterial cell walls attached to oil droplets.癌症免疫疗法：在皮内注射附着于油滴的分枝杆菌细胞壁后，已形成的皮内肿瘤出现消退。
J Natl Cancer Inst. 1974 May;52(5):1571-7. doi: 10.1093/jnci/52.5.1571.
4
BCG and cancer (first of two parts).卡介苗与癌症（两部分中的第一部分）
N Engl J Med. 1974 Jun 20;290(25):1413-20. doi: 10.1056/NEJM197406202902506.
5
Biologically active components from mycobacterial cell walls. II. Suppression and regression of strain-2 guinea pig hepatoma.分枝杆菌细胞壁的生物活性成分。II. 2型豚鼠肝癌的抑制与消退
J Natl Cancer Inst. 1974 Jan;52(1):103-11. doi: 10.1093/jnci/52.1.103.
6
Transplantable hepatomas induced in strain-2 guinea pigs by diethylnitrosamine: characterization by histology, growth, and chromosomes.
J Natl Cancer Inst. 1969 Oct;43(4):821-31.
7
Immunotherapy of human malignant melanoma with oil-attached BCG cell-wall skeleton.用人用卡介苗细胞壁骨架油剂进行人恶性黑色素瘤的免疫治疗。
Gan. 1975 Aug;66(4):355-63.
8
Clinical and immunologic studies of disseminated BCG infection.播散性卡介苗感染的临床与免疫学研究
Cancer. 1978 May;41(5):1771-80. doi: 10.1002/1097-0142(197805)41:5<1771::aid-cncr2820410519>3.0.co;2-c.
9
Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Int J Cancer. 1977 Jun 15;19(6):818-21. doi: 10.1002/ijc.2910190612.
10
Immunotherapy of cancer with nonliving mycobacteria and cord factor (trehalose-6,6'-dimycolate) in aqueous medium.
J Natl Cancer Inst. 1976 Oct;57(4):963-4. doi: 10.1093/jnci/57.4.963.

用分枝杆菌疫苗对豚鼠肝癌进行免疫治疗：卡介苗细胞壁与细胞壁骨架的比较

Immunotherapy of a guinea pig hepatoma with mycobacterial vaccines: comparison of BCG cell walls and cell wall skeletons.

作者信息

Yarkoni E, Rapp H J

出版信息

Infect Immun. 1978 Sep;21(3):1029-32. doi: 10.1128/iai.21.3.1029-1032.1978.

DOI:10.1128/iai.21.3.1029-1032.1978
PMID:361572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422101/
Abstract

BCG cell wall skeletons (SK) derived from BCG cell walls (CW) by treatment with proteolytic enzymes and organic solvents were tested for their potency to cause regression of a transplanted guinea pig hepatoma. On a weight basic, SK were as effective as CW in causing tumor regression, and they, as well as purified protein derivative of mycobacteria, provoked delayed cutaneous hypersensitivity reactions in animals immunized with CW or with SK. On a weight basis, CW were more active than SK in eliciting delayed cutaneous hypersensitivity in sensitized guinea pigs whether the animals were immunized with CW or with SK. In unimmunized animals the inflammatory response to intradermally administered CW was greater than that evoked by SK. CW and SK provoked delayed cutaneous hypersensitivity reactions of similar strength in animals immunized with living BCG. This study provided no compelling reasons for using SK instead of CW in clinical trials of cancer treatment by mycobacterial vaccines.

摘要

通过用蛋白水解酶和有机溶剂处理卡介苗细胞壁（CW）而获得的卡介苗细胞壁骨架（SK），对其使移植的豚鼠肝癌消退的效力进行了测试。以重量为基础，SK在引起肿瘤消退方面与CW一样有效，并且它们以及分枝杆菌的纯化蛋白衍生物，在经CW或SK免疫的动物中引发了迟发型皮肤超敏反应。以重量为基础，无论是用CW还是SK免疫动物，在致敏豚鼠中，CW在引发迟发型皮肤超敏反应方面比SK更活跃。在未免疫的动物中，对皮内注射CW的炎症反应大于SK所引发的炎症反应。CW和SK在经活卡介苗免疫的动物中引发了强度相似的迟发型皮肤超敏反应。这项研究没有提供令人信服的理由在分枝杆菌疫苗癌症治疗的临床试验中使用SK而非CW。