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1
Immunotherapy of experimental cancer by intralesional injection of emulsified nonliving mycobacteria: comparison of Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis.通过瘤内注射乳化的非活性分枝杆菌进行实验性癌症免疫治疗：牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌的比较
Infect Immun. 1980 Jun;28(3):887-92. doi: 10.1128/iai.28.3.887-892.1980.
2
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally injected emulsions containing heat-killed Nocardia rubra, Mycobacterium bovis (BCG) and Mycobacterium phlei.用移植性肝癌对豚鼠进行免疫治疗：对瘤内注射含有热灭活红色诺卡氏菌、牛型分枝杆菌（卡介苗）和草分枝杆菌的乳剂的比较。
Oncology. 1982;39(5):314-8. doi: 10.1159/000225659.
3
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.用移植性肝癌对豚鼠进行免疫治疗：瘤内注射灭活卡介苗细胞与卡介苗细胞壁的比较
Infect Immun. 1979 Sep;25(3):1087-9. doi: 10.1128/iai.25.3.1087-1089.1979.
4
Immunotherapy of a guinea pig hepatoma with mycobacterial vaccines: comparison of BCG cell walls and cell wall skeletons.用分枝杆菌疫苗对豚鼠肝癌进行免疫治疗：卡介苗细胞壁与细胞壁骨架的比较
Infect Immun. 1978 Sep;21(3):1029-32. doi: 10.1128/iai.21.3.1029-1032.1978.
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Immunotherapy of cancer: tumor suppression and regression by cell walls of Mycobacterium phlei attached to oil droplets.癌症免疫疗法：附着于油滴上的草分枝杆菌细胞壁对肿瘤的抑制与消退作用
J Natl Cancer Inst. 1975 Sep;55(3):727-30. doi: 10.1093/jnci/55.3.727.
6
Immunotherapy of guinea pigs with dermal and visceral tumor implants: comparison of living and nonliving BCG.用皮肤和内脏肿瘤植入物对豚鼠进行免疫治疗：活卡介苗与灭活卡介苗的比较
Infect Immun. 1979 May;24(2):565-66. doi: 10.1128/iai.24.2.565-566.1979.
7
Various antigenic reactivities in delayed hypersensitivity among crystalline proteins from Mycobacterium phlei.
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8
Responses of tumors induced in inbred guinea pig strain JY=1 and strain Hartley/F to BCG.近交系豚鼠JY = 1株和Hartley/F株中诱导产生的肿瘤对卡介苗的反应。
J Natl Cancer Inst. 1977 Mar;58(3):803-8. doi: 10.1093/jnci/58.3.803.
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Cross-reactions between mycobacteria. II. Crossed immunoelectrophoretic analysis of soluble antigens of BCG and comparison with other mycobacteria.分枝杆菌之间的交叉反应。II. 卡介苗可溶性抗原的交叉免疫电泳分析及其与其他分枝杆菌的比较。
Scand J Immunol. 1979;9(2):115-24. doi: 10.1111/j.1365-3083.1979.tb02713.x.
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Evaluation of bovine cutaneous delayed-type hypersensitivity (DTH) to various test antigens and a mitogen using several adjuvants.使用多种佐剂评估牛对各种测试抗原和一种丝裂原的皮肤迟发型超敏反应（DTH）。
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Closely related mycobacterial strains demonstrate contrasting levels of efficacy as antitumor vaccines and are processed for major histocompatibility complex class I presentation by multiple routes in dendritic cells.密切相关的分枝杆菌菌株作为抗肿瘤疫苗表现出不同程度的疗效，并通过树突状细胞中的多种途径进行主要组织相容性复合体I类呈递。
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A specific vaccine effective against stage I and stage II malignant disease in guinea pigs. Effect of variations in preparations and storage.一种对豚鼠I期和II期恶性疾病有效的特定疫苗。制剂和储存变化的影响。
Cancer Immunol Immunother. 1982;14(2):92-5. doi: 10.1007/BF00200174.

本文引用的文献

1
Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs.油的类型和表面活性剂浓度对乳化的牛分枝杆菌卡介苗细胞壁诱导豚鼠肿瘤消退功效的影响。
Infect Immun. 1980 Jun;28(3):881-6. doi: 10.1128/iai.28.3.881-886.1980.
2
Immunotherapy of cancer: regression of established intradermal tumors after intralesional injection of mycobacterial cell walls attached to oil droplets.癌症免疫疗法：在皮内注射附着于油滴的分枝杆菌细胞壁后，已形成的皮内肿瘤出现消退。
J Natl Cancer Inst. 1974 May;52(5):1571-7. doi: 10.1093/jnci/52.5.1571.
3
A guinea pig model for tumor immunology. A summary.肿瘤免疫学的豚鼠模型。综述。
Isr J Med Sci. 1973 Mar;9(3):366-74.
4
Immunotherapy of cancer: tumor suppression and regression by cell walls of Mycobacterium phlei attached to oil droplets.癌症免疫疗法：附着于油滴上的草分枝杆菌细胞壁对肿瘤的抑制与消退作用
J Natl Cancer Inst. 1975 Sep;55(3):727-30. doi: 10.1093/jnci/55.3.727.
5
Influence of oil concentration on the efficacy of tumor regression by emulsified components of mycobacteria.油浓度对分枝杆菌乳化成分肿瘤消退疗效的影响。
Cancer Res. 1979 Feb;39(2 Pt 1):535-7.
6
Intralesional immunotherapy of malignant melanoma with mycobacterium smegmatis cell wall skeleton combined with trehalose dimycolate (P3).用耻垢分枝杆菌细胞壁骨架联合海藻糖二霉菌酸酯对恶性黑色素瘤进行瘤内免疫治疗（P3）。
Cancer. 1979 Aug;44(2):495-503. doi: 10.1002/1097-0142(197908)44:2<495::aid-cncr2820440220>3.0.co;2-b.
7
Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.在病灶内注射用2,6,10,15,19,23-六甲基-2,6,10,14,18,22-二十四碳六烯（角鲨烯）、2,6,10,15,19,23-六甲基二十四烷（角鲨烷）、花生油或矿物油乳化的分枝杆菌成分后肿瘤消退情况。
Cancer Res. 1979 May;39(5):1518-20.
8
Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.用移植性肝癌对豚鼠进行免疫治疗：瘤内注射灭活卡介苗细胞与卡介苗细胞壁的比较
Infect Immun. 1979 Sep;25(3):1087-9. doi: 10.1128/iai.25.3.1087-1089.1979.
9
Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration.
Int J Cancer. 1977 Jun 15;19(6):818-21. doi: 10.1002/ijc.2910190612.

通过瘤内注射乳化的非活性分枝杆菌进行实验性癌症免疫治疗：牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌的比较

Immunotherapy of experimental cancer by intralesional injection of emulsified nonliving mycobacteria: comparison of Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis.

作者信息

Yarkoni E, Rapp H J

出版信息

Infect Immun. 1980 Jun;28(3):887-92. doi: 10.1128/iai.28.3.887-892.1980.

DOI:10.1128/iai.28.3.887-892.1980
PMID:6995326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551034/
Abstract

Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis were each tested in emulsified form for their potency to cause regression of transplants of a syngeneic murine fibrosarcoma and of a syngeneic guinea pig hepatoma. On a weight basis, M. phlei and M. smegmatis were as effective as BCG in causing tumor regression. M. phlei and M. smegmatis were comparable to BCG in provoking delayed cutaneous hypersensitivity reactions in guinea pigs sensitized to M. phlei or M. smegmatis. In BCG-sensitized guinea pigs, M. phlei and M. smegmatis provoked weaker delayed cutaneous hypersensitivity reactions than did BCG. Purified protein derivative of M. tuberculosis was more active in eliciting delayed cutaneous hypersensitivity in BCG-sensitized guinea pigs than in animals sensitized with M. phlei or M. smegmatis.

摘要

对牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌进行了乳化形式的测试，以检验它们使同基因小鼠纤维肉瘤移植瘤和同基因豚鼠肝癌移植瘤消退的效力。按重量计算，草分枝杆菌和耻垢分枝杆菌在引起肿瘤消退方面与卡介苗同样有效。在对草分枝杆菌或耻垢分枝杆菌致敏的豚鼠中，草分枝杆菌和耻垢分枝杆菌在引发迟发性皮肤超敏反应方面与卡介苗相当。在卡介苗致敏的豚鼠中，草分枝杆菌和耻垢分枝杆菌引发的迟发性皮肤超敏反应比卡介苗弱。结核分枝杆菌的纯化蛋白衍生物在卡介苗致敏的豚鼠中比在草分枝杆菌或耻垢分枝杆菌致敏的动物中更能有效地引发迟发性皮肤超敏反应。