通过瘤内注射乳化的非活性分枝杆菌进行实验性癌症免疫治疗：牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌的比较
Immunotherapy of experimental cancer by intralesional injection of emulsified nonliving mycobacteria: comparison of Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis.
作者信息
Yarkoni E, Rapp H J
出版信息
Infect Immun. 1980 Jun;28(3):887-92. doi: 10.1128/iai.28.3.887-892.1980.
Abstract
Mycobacterium bovis (BCG), Mycobacterium phlei, and Mycobacterium smegmatis were each tested in emulsified form for their potency to cause regression of transplants of a syngeneic murine fibrosarcoma and of a syngeneic guinea pig hepatoma. On a weight basis, M. phlei and M. smegmatis were as effective as BCG in causing tumor regression. M. phlei and M. smegmatis were comparable to BCG in provoking delayed cutaneous hypersensitivity reactions in guinea pigs sensitized to M. phlei or M. smegmatis. In BCG-sensitized guinea pigs, M. phlei and M. smegmatis provoked weaker delayed cutaneous hypersensitivity reactions than did BCG. Purified protein derivative of M. tuberculosis was more active in eliciting delayed cutaneous hypersensitivity in BCG-sensitized guinea pigs than in animals sensitized with M. phlei or M. smegmatis.
摘要
对牛分枝杆菌（卡介苗）、草分枝杆菌和耻垢分枝杆菌进行了乳化形式的测试，以检验它们使同基因小鼠纤维肉瘤移植瘤和同基因豚鼠肝癌移植瘤消退的效力。按重量计算，草分枝杆菌和耻垢分枝杆菌在引起肿瘤消退方面与卡介苗同样有效。在对草分枝杆菌或耻垢分枝杆菌致敏的豚鼠中，草分枝杆菌和耻垢分枝杆菌在引发迟发性皮肤超敏反应方面与卡介苗相当。在卡介苗致敏的豚鼠中，草分枝杆菌和耻垢分枝杆菌引发的迟发性皮肤超敏反应比卡介苗弱。结核分枝杆菌的纯化蛋白衍生物在卡介苗致敏的豚鼠中比在草分枝杆菌或耻垢分枝杆菌致敏的动物中更能有效地引发迟发性皮肤超敏反应。
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