Rosenberg S A, Seipp C, Sears H F
Cancer. 1978 May;41(5):1771-80. doi: 10.1002/1097-0142(197805)41:5<1771::aid-cncr2820410519>3.0.co;2-c.
Eight patients with disseminated BCG infection following injection of BCG into primary melanomas have been studied. These patients developed persistent fevers beginning 9 to 20 days following BCG injection. Severe liver function abnormalities occurred in all patients and peaked approximately 20 days following BCG injection. The persistent fevers, and clinical signs and symptoms of disseminated BCG infection lasted from 7 to 22 days before subsiding. Liver function abnormalities sometimes took six months to return to normal. Evidence of granulomas in liver and bone marrow were present. The natural course of this disease did not appear to be affected by therapy with isoniazid (INH). In vitro immunologic studies revealed a severe depression of lymphocyte reactivity in five of six patients sequentially tested. Wide dissemination of BCG from the site of injection is a severe complication of BCG therapy. The clinical course of this disease and suggestions for management are described in this paper.
对8例在原发性黑色素瘤内注射卡介苗后发生播散性卡介苗感染的患者进行了研究。这些患者在卡介苗注射后9至20天开始出现持续发热。所有患者均出现严重肝功能异常，且在卡介苗注射后约20天达到峰值。播散性卡介苗感染的持续发热以及临床体征和症状持续7至22天后方消退。肝功能异常有时需要6个月才能恢复正常。肝脏和骨髓中存在肉芽肿证据。异烟肼（INH）治疗似乎未影响该疾病的自然病程。体外免疫学研究显示，在依次检测的6例患者中有5例淋巴细胞反应性严重降低。卡介苗从注射部位广泛播散是卡介苗治疗的一种严重并发症。本文描述了该疾病的临床病程及处理建议。
