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外泌体相关PIGR在结直肠癌脂肪酸代谢和免疫信号传导中的潜在作用

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer.

作者信息

Liu Ying, Hu Yongbin, Deng Langmei

机构信息

Department of Pathology, Xiangya Changde Hospital, Changde, China.

Department of Pathology, Basic Medical School, Central South University, Changsha, China.

出版信息

J Oncol. 2022 Sep 15;2022:4675683. doi: 10.1155/2022/4675683. eCollection 2022.

DOI:10.1155/2022/4675683
PMID:36157233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9499750/
Abstract

The polymeric immunoglobulin receptor (PIGR), an exosome-associated glycoprotein, plays an important role in the occurrence and development of different tumors. This study aimed to investigate whether PIGR is essential for colorectal cancer (CRC). Comprehensive bioinformatics analysis and immunohistochemistry (IHC) revealed that expression of PIGR was significantly decreased in CRC patients. Upregulated PIGR displayed favorable prognostic values in CRC patients. Several algorithms, such as TISIDB and TIMER, were used to evaluate the roles of PIGR expression in the regulation of immune response in CRC. Moreover, GSEA enrichment analysis indicated the underlying role of PIGR in the regulation of fatty acid metabolism in CRC. Taken together, our findings might provide a new potential prognostic and immune-associated biomarker for CRC and supply a new destination for PIGR-related immunotherapy in clinical treatment.

摘要

多聚免疫球蛋白受体（PIGR）是一种与外泌体相关的糖蛋白，在不同肿瘤的发生和发展中起重要作用。本研究旨在探讨PIGR对结直肠癌（CRC）是否至关重要。综合生物信息学分析和免疫组织化学（IHC）显示，CRC患者中PIGR的表达显著降低。PIGR表达上调在CRC患者中显示出良好的预后价值。使用了几种算法，如TISIDB和TIMER，来评估PIGR表达在CRC免疫反应调节中的作用。此外，基因集富集分析（GSEA）表明PIGR在CRC脂肪酸代谢调节中的潜在作用。综上所述，我们的研究结果可能为CRC提供一种新的潜在预后和免疫相关生物标志物，并为临床治疗中与PIGR相关的免疫治疗提供新的方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2060/9499750/6460d4767a5e/JO2022-4675683.007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2060/9499750/6460d4767a5e/JO2022-4675683.007.jpg

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