Lin Guo-Dong, Wu Jie-Yi, Peng Xiao-Bo, Lu Xiao-Xia, Liu Zhong-Ying, Pan Zhi-Guo, Qiu Ze-Wu, Dong Jian-Guang
Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, Guangdong Province, China.
Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
World J Clin Cases. 2022 Sep 6;10(25):8872-8879. doi: 10.12998/wjcc.v10.i25.8872.
Misuse of disinfectants during the coronavirus disease 2019 pandemic has led to several poisoning incidents. However, there are few clinical case reports on poisoning caused by improper mixing of household disinfectants.
To summarize the clinical characteristics and treatment effects of chlorine poisoning caused by improper mixing of hypochlorite bleach with acidic cleaning agents.
METHODSWe retrospectively analyzed baseline and clinical data, clinical symptoms, and treatment methods of seven patients with chlorine poisoning who were admitted to the National Army Poisoning Treatment Center.
Among the seven patients, the average poisoning time (exposure to admission) was 57 h (4-240 h). All patients were involved in cleaning bathrooms. Chest computed tomography scans revealed bilateral lung effusions or inflammatory changes in five patients. The partial pressure of oxygen decreased in six patients, and respiratory failure occurred in one. Five patients had different degrees of increase in white blood cell count. Humidified oxygen therapy, non-invasive mechanical ventilation, anti-inflammatory corticosteroids, antioxidants, and antibiotics were administered for treatment. The average length of hospital stay was 7 d (4-9 d). All seven patients recovered and were discharged.
Improper mixing of household disinfectants may cause damage to the respiratory system due to chlorine poisoning. Corticosteroids may improve lung exudation in severe cases, and symptomatic supportive treatment should be performed early.
2019年冠状病毒病大流行期间消毒剂的不当使用导致了多起中毒事件。然而，关于家用消毒剂不当混合引起中毒的临床病例报告很少。
总结次氯酸盐漂白剂与酸性清洁剂不当混合导致氯中毒的临床特征及治疗效果。
方法 我们回顾性分析了7例入住中国人民解放军中毒救治中心的氯中毒患者的基线和临床资料、临床症状及治疗方法。
7例患者中，平均中毒时间（接触至入院）为57小时（4 - 240小时）。所有患者均参与浴室清洁。胸部计算机断层扫描显示5例患者双侧胸腔积液或炎症改变。6例患者氧分压降低，1例发生呼吸衰竭。5例患者白细胞计数有不同程度升高。给予吸氧湿化治疗、无创机械通气、抗炎糖皮质激素、抗氧化剂及抗生素进行治疗。平均住院时间为7天（4 - 9天）。7例患者均康复出院。
家用消毒剂不当混合可能因氯中毒导致呼吸系统损害。糖皮质激素在重症病例中可能改善肺部渗出，应尽早进行对症支持治疗。
