Sherwin B B, Gelfand M M
Psychosom Med. 1987 Jul-Aug;49(4):397-409. doi: 10.1097/00006842-198707000-00009.
Five aspects of sexual behavior were monitored daily in three groups of women who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy approximately 4 years ago for benign disease. One group had been receiving an estrogen-androgen preparation intramuscularly once a month since their surgery (E-A). The second group had been receiving estrogen alone (E) and the third group of women had remained untreated. Plasma estradiol and testosterone were measured at an established baseline and again on days 2, 4, 8, 15, 21, and 28 postinjection. Women who received both sex steroids reported higher rates of sexual desire (p less than 0.01), sexual arousal (p less than 0.01), and numbers of fantasies (p less than 0.01) than those who were either given E or who were untreated. Moreover, changes in these behaviors covaried with plasma testosterone but not with plasma estradiol levels during the treatment month as the drug was being metabolized. Rates of coitus and orgasm were also higher in the E-A group during the first two postinjection weeks (p less than 0.01) coincident with their higher testosterone levels. These findings imply that androgen may be critical for the maintenance of optimal levels of sexual functioning in postmenopausal women.
对三组约4年前因良性疾病接受了全腹子宫切除术及双侧输卵管卵巢切除术的女性，每日监测其性行为的五个方面。一组自手术后每月接受一次肌肉注射雌激素 - 雄激素制剂（E - A组）。第二组仅接受雌激素（E组），第三组女性未接受任何治疗。在既定基线时以及注射后第2、4、8、15、21和28天测量血浆雌二醇和睾酮水平。与接受雌激素治疗或未接受治疗的女性相比，同时接受两种性类固醇的女性报告的性欲（p < 0.01）、性唤起（p < 0.01）和幻想次数（p < 0.01）更高。此外，在治疗月药物代谢期间，这些行为的变化与血浆睾酮水平相关，而与血浆雌二醇水平无关。在前两个注射后周内，E - A组的性交和性高潮发生率也更高（p < 0.01），这与其较高的睾酮水平一致。这些发现表明，雄激素可能对维持绝经后女性的最佳性功能水平至关重要。
