Yatvin M B, Vorpahl J W, Ghosh S K, Kim U, Elson C E
Radiat Environ Biophys. 1987;26(2):89-101. doi: 10.1007/BF01211404.
Paired lines of metastasizing and non-metastasizing transplantable rat mammary tumors were studied for their sensitivity to hyperthermia. The metastasizing TMT-081 and SMT-2A tumors were markedly more sensitive to heat injury as measured by tumor growth delay than were their non-metastatic counterparts MT-100 and MT-W9B. The metastasizing MT-081 tumor was also significantly more sensitive than the SMT-2A tumor. The differences in heat sensitivity were not the result of differences in intra-tumor temperatures attained during water bath heating. A more likely explanation for the variable response obtained with these tumors after heat treatment may be the inherent differences in stability and composition of their cellular membranes, particularly the plasma membrane.
对转移性和非转移性可移植大鼠乳腺肿瘤的配对品系进行了热敏感性研究。通过肿瘤生长延迟来衡量，转移性TMT - 081和SMT - 2A肿瘤比其非转移性对应物MT - 100和MT - W9B对热损伤明显更敏感。转移性MT - 081肿瘤也比SMT - 2A肿瘤显著更敏感。热敏感性的差异并非水浴加热过程中肿瘤内部温度差异的结果。这些肿瘤热处理后获得的可变反应更可能的解释可能是其细胞膜，特别是质膜的稳定性和组成存在固有差异。
