Department of General Surgery, Wuhan University of Science and Technology Hospital, China 430065.
The First Affiliated Hospital of Nanjing Medical University (Department of Oncology), China 210029.
Comput Math Methods Med. 2022 Sep 14;2022:9277847. doi: 10.1155/2022/9277847. eCollection 2022.
Gastric cancer pathological biopsy and visual examination have been the gold standard for gastric cancer diagnosis, but their operation is costly, demanding, and risky, so it is especially important to find an effective examination method in clinical practice.
To investigate the correlation between serum pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen I and II ratio (PGR), IL-6, and TNF- and Helicobacter pylori (Hp) infection in patients with gastric cancer.
Fifty patients with Hp-infected gastric cancer admitted to the Department of Gastroenterology of our hospital from January 2019 to December 2021 were selected for the study as the observation group, and another 50 patients without Hp-infected gastric cancer were selected as the comparison group to compare the correlation analysis of PGI, PGII, PGR, IL-6, and TNF- with Hp infection between the two groups after admission and treatment.
After measurement, PGI and PGII in the observation group were significantly lower than those in the comparison group, and TNF-, IL-18, and IL-6 in the observation group were significantly higher than those in the comparison group, and the comparative differences were all statistically significant ( < 0.05). The results of multivariate logistic regression model analysis of independent risk factors for gastric cancer showed that IL-18, hs-CRP, and tumor necrosis factor- (TNF-) were risk factors for Hp infection in gastric cancer.
The expression of IL-18, hs-CRP, and TNF- factors in Hp-infected gastric cancer patients is correlated. IL-6, IL-18, and TNF- are involved in the entire process from the onset to the development of Hp-positive gastric mucosal inflammation in patients, which is of great value in the diagnosis of gastric cancer and helps to assess the degree of progression and prognosis of gastric cancer.
胃癌病理活检和肉眼观察一直是胃癌诊断的金标准，但操作成本高、要求高且有风险，因此在临床实践中寻找一种有效的检查方法尤为重要。
探讨胃癌患者血清胃蛋白酶原 I（PGI）、胃蛋白酶原 II（PGII）、PGI 与 PGII 比值（PGR）、白细胞介素 6（IL-6）和肿瘤坏死因子-（TNF-）与幽门螺杆菌（Hp）感染的相关性。
选择 2019 年 1 月至 2021 年 12 月我院消化内科收治的 50 例 Hp 感染胃癌患者作为观察组，另选同期收治的 50 例无 Hp 感染的胃癌患者作为对照组，比较两组患者入院及治疗后的 PGI、PGII、PGR、IL-6、TNF-与 Hp 感染的相关性分析。
经测量，观察组的 PGI 和 PGII 明显低于对照组，观察组的 TNF-、IL-18 和 IL-6 明显高于对照组，对比差异均具有统计学意义（<0.05）。胃癌 Hp 感染的独立危险因素多因素 logistic 回归模型分析结果显示，IL-18、hs-CRP 和肿瘤坏死因子-（TNF-）是胃癌 Hp 感染的危险因素。
Hp 感染胃癌患者的 IL-18、hs-CRP 和 TNF- 表达相关。IL-6、IL-18 和 TNF- 参与了 Hp 阳性胃黏膜炎症从发病到发展的全过程，对胃癌的诊断具有重要价值，有助于评估胃癌的进展程度和预后。
