Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China.

OBJECTIVE

One of the causes of hypertension is a genetic factor. The purpose of this study was to look at the relationship between apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms and essential hypertension in the Hakka population.

METHODS

The study included 2,850 patients with hypertension and 2,034 controls. rs429358, rs7412, and rs1801133 were genotyped by polymerase chain reaction (PCR)-microarray. The differences in these polymorphisms between the two groups were analyzed.

RESULTS

The genotype and allele frequency of and polymorphisms did not differ significantly between hypertensive patients and controls. Patients with hypertension who were rs429358C/C homozygous had higher TG, TC, LDL-C, and Apo-B levels, whereas patients with the T/T genotype had higher HDL-C levels. Patients with hypertension who were rs7412T/T homozygous had higher TG and TC levels and lower LDL-C and Apo-B levels. Homocysteine (Hcy) levels in patients with CC, CT, and TT genotypes were increased, while patients with the TT genotype and T allele had higher Hcy levels than those of patients with other genotypes and the C allele. The rs7412T/T genotype in the co-dominant model ( rs7412T/T vs. C/C) (gender-, age-, smoking-, and drinking-adjusted OR 2.682, 95% CI, 1.072-6.710, =0.035) was a significant risk factor for hypertension. The rs429358 and rs1801133 genotypes in co-dominant, dominant, and recessive models were not significant risk factors for hypertension.

CONCLUSIONS

It supports that polymorphisms are related to hypertension in the Hakka population. Specifically, the rs7412T/T genotype may be a risk factor for hypertension.