Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Department of Tuberculosis Control and Prevention, Guangzhou Chest Hospital, Guangzhou, China.
Front Public Health. 2022 Sep 7;10:906798. doi: 10.3389/fpubh.2022.906798. eCollection 2022.
Drug-resistant tuberculosis remains a serious public health problem worldwide, particularly in developing countries, including China. This study determined treatment outcomes among a cohort in Guangzhou, China, and identified factors associated with them.
We initiated a retrospective study using drug-resistant TB data in Guangzhou from 2016 to 2020, managed by Guangzhou Chest Hospital. A competing risk model was used to identify the factors associated with treatment failure and death, as well as loss to follow-up (LTFU).
A total of 809 patients were included in the study, of which 281 were under treatment. Of the remaining 528 who had clear treatment outcomes, the number and proportion of treatment success, treatment failure, death, and LTFU were 314 (59.5%), 14 (2.7%), 32 (6.0%), and 168 (31.8%), respectively. Being older and having cavities involving the upper lungs were risk factors for treatment failure and death, while non-Guangzhou household registration and interprovincial mobility were risk factors associated with LTFU.
Treatment failure and death were significantly associated with cavitation in the lungs, and LTFU was significantly associated with household registration and geographical mobility. Early identification of factors associated with different treatment outcomes is extremely important for policymakers, health experts, and researchers to implement appropriate strategies and measures to treat and manage the TB-infected population in China.
耐药结核病仍然是全球范围内一个严重的公共卫生问题，尤其是在包括中国在内的发展中国家。本研究旨在确定中国广州某队列的治疗结果，并确定与这些结果相关的因素。
我们利用广州胸科医院管理的 2016 年至 2020 年广州耐药结核病数据开展了一项回顾性研究。采用竞争风险模型确定与治疗失败和死亡以及失访（LTFU）相关的因素。
本研究共纳入 809 例患者，其中 281 例正在接受治疗。在其余 528 例治疗结局明确的患者中，治疗成功、治疗失败、死亡和 LTFU 的例数和比例分别为 314 例（59.5%）、14 例（2.7%）、32 例（6.0%）和 168 例（31.8%）。年龄较大和上肺有空洞是治疗失败和死亡的危险因素，而非广州户籍和省际流动是 LTFU 的危险因素。
治疗失败和死亡与肺部空洞显著相关，LTFU 与户籍和地域流动显著相关。早期识别与不同治疗结果相关的因素对于政策制定者、卫生专家和研究人员实施适当的策略和措施来治疗和管理中国的结核感染人群至关重要。
