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玻璃体内注射康柏西普治疗大泡性视网膜脱离：一例报告。

Intravitreous injection of conbercept for bullous retinal detachment: A case report.

作者信息

Xiang Xiao-Li, Cao Yi-Hong, Jiang Ting-Wang, Huang Zheng-Ru

机构信息

Department of Ophthalmology, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu 215500, Jiangsu Province, China.

Department of Key Laboratory, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu 215500, Jiangsu Province, China.

出版信息

World J Clin Cases. 2022 Sep 16;10(26):9510-9517. doi: 10.12998/wjcc.v10.i26.9510.

DOI:10.12998/wjcc.v10.i26.9510
PMID:36159403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9477655/
Abstract

BACKGROUND

Diffuse retinal pigment epitheliopathy (DRPE) associated with bullous retinal detachment is a severe variant of DRPE that is frequently misdiagnosed and often improperly treated.

CASE SUMMARY

A 36-year-old female patient complained of "painless vision decline in the left eye with obscuration for 10 d". Slit-lamp microscopic fundus examination revealed white-yellow subretinal exudates in the posterior pole in both eyes, retinal detachment with shifting subretinal fluid in the left eye, and no retinal hiatus. Fundus fluorescein angiography revealed multiple subretinal leakage foci and localized hypofluorescent lesions with patched hyperfluorescence. There was fluorescence leakage in the retinal vessels in the retinal detachment area and occluded blood vessels in the lower and peripheral areas. Indocyanine green angiography revealed multifocal lamellar hyperfluorescence in the middle stage and low fluorescence in the retinal detachment area in the late stage. Retinal anatomical reduction significantly improved with intravitreal conbercept injections.

CONCLUSION

Intravitreal injection of conbercept can anatomically reattach the retina in patients with bullous retinal detachment.

摘要

背景

与大泡性视网膜脱离相关的弥漫性视网膜色素上皮病变（DRPE）是DRPE的一种严重变体，常被误诊且治疗不当。

病例摘要

一名36岁女性患者主诉“左眼无痛性视力下降伴视物模糊10天”。裂隙灯显微镜眼底检查显示双眼后极部有白黄色视网膜下渗出物，左眼视网膜脱离伴视网膜下液移位，无视网膜裂孔。眼底荧光血管造影显示多个视网膜下渗漏灶以及局限性低荧光病变伴斑片状高荧光。视网膜脱离区域的视网膜血管有荧光渗漏，下方及周边区域血管闭塞。吲哚菁绿血管造影显示中期多灶性片状高荧光，晚期视网膜脱离区域低荧光。玻璃体内注射康柏西普后视网膜解剖复位明显改善。

结论

玻璃体内注射康柏西普可使大泡性视网膜脱离患者的视网膜实现解剖复位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/adf212f22c42/WJCC-10-9510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/b36effef61b6/WJCC-10-9510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/6d9208ef584a/WJCC-10-9510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/3dc36f96a095/WJCC-10-9510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/adf212f22c42/WJCC-10-9510-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/b36effef61b6/WJCC-10-9510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/6d9208ef584a/WJCC-10-9510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/3dc36f96a095/WJCC-10-9510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e316/9477655/adf212f22c42/WJCC-10-9510-g004.jpg

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本文引用的文献

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Bullous Central Serous Chorioretinopathy: A Rare and Atypical Form of Central Serous Chorioretinopathy. A Systematic Review.大疱性中心性浆液性脉络膜视网膜病变：一种罕见且非典型的中心性浆液性脉络膜视网膜病变。系统评价
Pharmaceuticals (Basel). 2020 Aug 28;13(9):221. doi: 10.3390/ph13090221.
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Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.中心性浆液性脉络膜视网膜病变：危险因素、发病机制和影像学检查方法的最新进展。
Prog Retin Eye Res. 2020 Nov;79:100865. doi: 10.1016/j.preteyeres.2020.100865. Epub 2020 May 11.
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The Efficacy of Intravitreal Conbercept for Chronic Central Serous Chorioretinopathy.
玻璃体内注射康柏西普治疗慢性中心性浆液性脉络膜视网膜病变的疗效
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Photodynamic therapy for bullous retinal detachment: a single-center experience of case series with a 6-month follow-up study.光动力疗法治疗大泡性视网膜脱离：一项单中心病例系列6个月随访研究经验
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