Yang C M, Lin C P
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 1998 Oct;97(10):711-4.
Bullous retinal detachment, a severe and atypical presentation of central serous chorioretinopathy (CSCR), may develop in association with the use of systemic steroids. A 42-year-old man presented with a 2-month history of poor visual acuity in his right eye. A tentative diagnosis of Harada's syndrome was made and the patient was treated with large doses of systemic corticosteroids for 1 month, without improvement. Fundus examination showed bullous detachment with shifting subretinal fluid in both eyes. Fluorescein angiography demonstrated multiple leaking points with pigment epithelium detachment in both eyes. A diagnosis of bilateral severe CSCR was made and systemic steroid therapy was withdrawn. Several sessions of argon laser photocoagulation to the areas of fluorescein leakage in both eyes and transscleral drainage of subretinal fluid in the right eye were performed. Two months later, the retinae became attached in both eyes. Visual acuity in the right eye was limited by submacular fibrosis, while the visual acuity of the left eye was not affected. In summary, this case should alert physicians to suspect CSCR in patients with exudative retinal detachment, as the use of steroids is usually not only unnecessary but can also be harmful.
大泡性视网膜脱离是中心性浆液性脉络膜视网膜病变(CSCR)的一种严重且非典型表现,可能与全身使用类固醇有关。一名42岁男性患者右眼视力下降2个月。初步诊断为原田综合征,患者接受大剂量全身皮质类固醇治疗1个月,病情无改善。眼底检查显示双眼大泡性脱离伴视网膜下液移动。荧光素血管造影显示双眼多个渗漏点伴色素上皮脱离。诊断为双侧严重CSCR,停用全身类固醇治疗。对双眼荧光素渗漏区域进行了多次氩激光光凝,并对右眼进行了视网膜下液经巩膜引流。两个月后,双眼视网膜复位。右眼视力受黄斑下纤维化限制,而左眼视力未受影响。总之,该病例应提醒医生,对于渗出性视网膜脱离患者要怀疑CSCR,因为使用类固醇通常不仅不必要,而且可能有害。