Tosoratto Javier, Tárraga López Pedro Juan, López-González Ángel Arturo, Busquets-Cortes Carla, Obrador de Hevia Joan, Ramirez-Manent José Ignacio
ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain.
Faculty of Medicine, University of Castilla La Mancha (UCLM), 02008 Albacete, Castilla La Mancha, Spain.
J Clin Med. 2025 Jun 29;14(13):4604. doi: 10.3390/jcm14134604.
: Shift work has been increasingly associated with adverse metabolic outcomes, including insulin resistance (IR), a key contributor to cardiometabolic diseases. However, few large-scale studies have explored the association between shift work and validated IR indices across sociodemographic and lifestyle variables, stratified by sex. To investigate the relationship between shift work and four surrogate markers of insulin resistance-TyG índex, TyG-BMI, METS-IR (Metabolic score for insulin resistance), and SPISE-IR (Single-Point insulin Sensitivity estimator)-in a large Spanish working population and to assess how sociodemographic and behavioral factors modify these associations. : This cross-sectional study included 53,053 employed adults (31,753 men and 21,300 women) across various regions and labor sectors in Spain. Participants were classified as shift or non-shift workers based on their work schedules. Data were collected during routine occupational health assessments and included anthropometric, clinical, biochemical, and behavioral variables. IR indices were calculated using standard formulas. Statistical analyses included -tests, chi-square tests, and multivariable logistic regression, with stratification by sex. : Shift workers exhibited significantly higher levels of TyG, TyG-BMI, and METS-IR, and lower SPISE values compared to non-shift workers (all < 0.001). These differences persisted after stratification by sex, age, education, and lifestyle factors. Logistic regression analyses confirmed that shift work independently predicted high IR risk across all indices, with adjusted ORs ranging from 1.49 to 1.89. Physical inactivity, low adherence to the Mediterranean diet, and alcohol consumption were the strongest modifiable predictors. Men exhibited a higher burden of IR than women across all indices. : Shift work is independently associated with elevated insulin resistance in both men and women. These findings emphasize the importance of workplace health interventions targeting physical activity, diet, and substance use, particularly in populations engaged in non-standard work schedules.
轮班工作与不良代谢结果的关联日益增加，这些不良代谢结果包括胰岛素抵抗（IR），而胰岛素抵抗是心脏代谢疾病的一个关键因素。然而，很少有大规模研究探讨轮班工作与经社会人口统计学和生活方式变量分层、按性别划分的经过验证的胰岛素抵抗指数之间的关联。为了研究在西班牙的大量工作人群中轮班工作与胰岛素抵抗的四个替代指标——TyG指数、TyG-BMI、METS-IR（胰岛素抵抗代谢评分）和SPISE-IR（单点胰岛素敏感性估计值）之间的关系，并评估社会人口统计学和行为因素如何改变这些关联。：这项横断面研究纳入了西班牙不同地区和劳动部门的53053名在职成年人（31753名男性和21300名女性）。参与者根据工作时间表被分类为轮班或非轮班工作者。数据在常规职业健康评估期间收集，包括人体测量、临床、生化和行为变量。使用标准公式计算胰岛素抵抗指数。统计分析包括t检验、卡方检验和多变量逻辑回归，并按性别分层。：与非轮班工作者相比，轮班工作者的TyG、TyG-BMI和METS-IR水平显著更高，而SPISE值更低（所有P<0.001）。在按性别、年龄、教育程度和生活方式因素分层后，这些差异仍然存在。逻辑回归分析证实，轮班工作在所有指数中均独立预测高胰岛素抵抗风险，调整后的比值比范围为1.49至1.89。身体不活动、对地中海饮食的低依从性和饮酒是最强的可改变预测因素。在所有指数中，男性的胰岛素抵抗负担均高于女性。：轮班工作在男性和女性中均与胰岛素抵抗升高独立相关。这些发现强调了针对身体活动、饮食和物质使用的工作场所健康干预措施的重要性，特别是在从事非标准工作时间表的人群中。
