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生物高熵合金：进展、挑战与机遇。

Bio-high entropy alloys: Progress, challenges, and opportunities.

作者信息

Feng Junyi, Tang Yujin, Liu Jia, Zhang Peilei, Liu Changxi, Wang Liqiang

机构信息

School of Materials Engineering, Shanghai University of Engineering Science, Shanghai, China.

State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Front Bioeng Biotechnol. 2022 Sep 8;10:977282. doi: 10.3389/fbioe.2022.977282. eCollection 2022.

DOI:10.3389/fbioe.2022.977282
PMID:36159673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9492866/
Abstract

With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.

摘要

随着生物医学的不断进步与发展，金属生物医学材料引起了研究人员的广泛关注。由于传统金属植入材料与人体的兼容性较差，迫切需要开发具有优异力学性能和适当生物相容性的新型生物材料，以解决长期植入引起的不良反应。高熵合金（HEAs）是由五种或更多种元素组成的近等摩尔合金，具有巨大的成分设计空间和优异的力学性能。相比之下，生物高熵合金（Bio-HEAs）因其优异的生物相容性和可调节的力学性能，有望成为生物医学领域的新型生物合金。本文综述了近年来Bio-HEAs的成分体系，介绍了它们的生物相容性和与人体骨骼适配的力学性能，最后对Bio-HEAs的发展方向提出如下建议：完善Bio-HEAs成分设计的理论和模拟研究，量化成分、工艺、后处理对Bio-HEAs性能的影响，关注Bio-HEAs在实际服役条件下的损耗情况，希望新型医用合金Bio-HEAs能尽快实现临床应用。

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