Wereszczyńska-Siemiatkowska U, Nebendahl K, Pohl U, Otto J, Groene H J, Wilms H, Lankisch P G
Res Exp Med (Berl). 1987;187(3):211-6. doi: 10.1007/BF01852085.
Buprenorphine (15 micrograms/kg b.wt. per hour) distinctly reduced pain sensitivity in acute 3% sodium-taurocholate pancreatitis in male Wistar rats without interfering with the course of the disease. This was seen by assessment of enzyme elevation in serum and ascites and by histological evaluation of the pancreas. Buprenorphine is therefore recommended for animal experiments to study the effect of therapeutic principles in acute pancreatitis.
丁丙诺啡（每小时15微克/千克体重）可显著降低雄性Wistar大鼠急性3%牛磺胆酸钠诱导的胰腺炎的疼痛敏感性，且不干扰疾病进程。这一点可通过评估血清和腹水中的酶升高情况以及胰腺的组织学评估得以证实。因此，推荐在动物实验中使用丁丙诺啡来研究急性胰腺炎治疗原则的效果。
