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全球人类猴痘疫情与管理:一项综合文献综述

The Global Human Monkeypox Outbreak and Management: A Comprehensive Literature Review.

作者信息

Dighriri Ibrahim M, Braiji Shafiqah H, AlAnazi Malek M, Ayyashi Mona J, Khubrani Aisha A, Khormi Yasir B, Shbeir Lujain A, Alatif Sarah I, Alfagih Aisha E

机构信息

Department of Pharmacy, King Abdulaziz Specialist Hospital, Taif, SAU.

Department of Pharmacy, East Jeddah Hospital, Jeddah, SAU.

出版信息

Cureus. 2022 Dec 15;14(12):e32557. doi: 10.7759/cureus.32557. eCollection 2022 Dec.

Abstract

Monkeypox (MPX) belongs to the genus Orthopoxvirus (OPV), family Poxviridae, and sub-family Chordopoxvirinae. Human monkeypox (HMPX) is a viral zoonotic illness caused by the monkeypox virus (MPXV). Several non-endemic countries have confirmed MPX cases across the globe. Therefore, consider an outbreak to be a global health emergency. MPXV transmits from animals to humans via infected animals, and there is currently human-to-human transmission, notably among guys who have sexual relations with males. Healthcare interventions are required to stop outbreaks. These include strict isolation and care for MPX patients while they are still contagious or until the skin lesions dry out and crust over. JYNNEOS was approved as a vaccine for the prevention of MPXV. Tecovirimat is licensed to treat severe MPX or risk developing a serious disease. We should encourage international cooperation to conduct clinical trials investigating the effectiveness and safety of MPXV vaccines and antiviral medications. Precautions must be taken at the global level to prevent an MPXV outbreak.

摘要

猴痘(MPX)属于痘病毒科正痘病毒属和脊椎动物痘病毒亚科。人类猴痘(HMPX)是一种由猴痘病毒(MPXV)引起的病毒性人畜共患病。全球多个非流行国家已确诊猴痘病例。因此,将此次疫情视为全球卫生紧急事件。猴痘病毒通过受感染动物从动物传播给人类,目前存在人际传播,尤其是在与男性发生性关系的男性之间。需要采取医疗保健干预措施来阻止疫情爆发。这些措施包括在猴痘患者仍具传染性时或直至皮肤病变干燥结痂前对其进行严格隔离和护理。JYNNEOS被批准作为预防猴痘病毒的疫苗。特考韦瑞被许可用于治疗严重猴痘或有发展成严重疾病风险的情况。我们应鼓励国际合作开展临床试验,研究猴痘病毒疫苗和抗病毒药物的有效性和安全性。必须在全球层面采取预防措施以防止猴痘病毒爆发。

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本文引用的文献

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Monkeypox and Pregnancy: Latest Updates.猴痘与妊娠:最新进展。
Viruses. 2022 Nov 14;14(11):2520. doi: 10.3390/v14112520.
3
Reemergence of monkeypox: prevention and management.猴痘再现:预防与管理。
Expert Rev Anti Infect Ther. 2022 Nov;20(11):1425-1433. doi: 10.1080/14787210.2022.2128763. Epub 2022 Sep 30.
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Therapeutic strategies to address monkeypox.应对猴痘的治疗策略。
Expert Rev Anti Infect Ther. 2022 Oct;20(10):1249-1252. doi: 10.1080/14787210.2022.2113058. Epub 2022 Aug 17.
7
Monkeypox virus: a re-emergent threat to humans.猴痘病毒:对人类的再现威胁。
Virol Sin. 2022 Aug;37(4):477-482. doi: 10.1016/j.virs.2022.07.006. Epub 2022 Jul 9.
8
9
Monkeypox Outbreak - Nine States, May 2022.猴痘疫情爆发 - 九个州,2022 年 5 月。
MMWR Morb Mortal Wkly Rep. 2022 Jun 10;71(23):764-769. doi: 10.15585/mmwr.mm7123e1.

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