Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470Mülheim an der Ruhr, Germany.
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007Tarragona, Spain.
J Am Chem Soc. 2022 Oct 12;144(40):18223-18228. doi: 10.1021/jacs.2c06227. Epub 2022 Sep 26.
Herein we disclose a catalytic synthesis of cycloalkanols that harnesses the potential of NO as an oxygen transfer agent onto sp-hybridized carbons. The protocol is distinguished by its mild conditions and wide substrate scope, thus offering an opportunity to access carbocyclic compounds from simple precursors even in an enantioselective manner. Preliminary mechanistic studies suggest that the oxygen insertion event occurs at an alkylnickel species and that NO is the O transfer reagent.
在此，我们揭示了一种利用 NO 作为氧转移剂将 sp 杂化碳上的潜能应用于环烷醇合成的催化方法。该方案的特点是反应条件温和、底物适用范围广，因此即使在对映选择性方面，也能从简单的前体中获得碳环化合物。初步的机理研究表明，氧插入事件发生在烷基镍物种上，而 NO 是氧转移试剂。
