The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan 523808, China.
Department of Science and Education, The Dongguan Affiliated Hospital of Jinan University, Binhaiwan Central Hospital of Dongguan, Dongguan 523900, China.
Int J Pharm. 2022 Nov 5;627:122228. doi: 10.1016/j.ijpharm.2022.122228. Epub 2022 Sep 24.
Coordination chemistry has always been vital to explore the material prominence of metal-organic systems. The metal-organic chemistry plays a fundamental role in decisive structural features, which are accountable for tuning the properties of materials. Tumour therapy has become an important research field of medical treatment in the world. Metal-organic frameworks (MOFs) have attracted extensive interest in medical science research due to their large effective surface area, clear pore network, and critical catalytic performance. Compared with traditional MOF materials, MOF materials with core-shell structures have a higher loading rate and better stability, which can overcome a single function. They have been successfully used in tumour medical research and have excellent prospects for diagnosing and treating various tumours. The current review article thoroughly describes the various synthetic approaches for engineering core-shell MOF materials, the structural types, and the potential functional applications. We also discussed core-shell MOF materials for the various treatment of tumours, such as tumour chemotherapy, tumour phototherapy and tumour microenvironment anti-hypoxia therapy. In this paper, the synthesized procedures of core-shell MOFs and their applications for tumour treatment have been discussed, and their future research has prospected. The current improved strategies, challenges, and prospects are also presented because of the metal-organic chemistry governing the structural modification of core-shell MOFs for tumour therapy applications. Therefore, the present review article opens a new door for medicinal chemists to tune the structural features of the core-shell MOF materials to modulate tumour therapy with simple, low-cost materials for better human lives.
配位化学一直是探索金属有机体系材料重要性的关键。金属有机化学在决定材料性质的结构特征方面起着至关重要的作用。肿瘤治疗已成为世界医学治疗的一个重要研究领域。由于具有较大的有效表面积、清晰的孔网络和关键的催化性能，金属有机框架（MOFs）在医学科学研究中引起了广泛的关注。与传统的 MOF 材料相比，具有核壳结构的 MOF 材料具有更高的负载率和更好的稳定性，可以克服单一功能。它们已成功应用于肿瘤医学研究，在诊断和治疗各种肿瘤方面具有广阔的前景。本文综述了工程核壳 MOF 材料的各种合成方法、结构类型和潜在的功能应用。我们还讨论了核壳 MOF 材料在各种肿瘤治疗中的应用，如肿瘤化学治疗、肿瘤光疗和肿瘤微环境抗缺氧治疗。本文讨论了核壳 MOFs 的合成方法及其在肿瘤治疗中的应用，并对其未来的研究进行了展望。由于金属有机化学控制着核壳 MOFs 的结构修饰，以用于肿瘤治疗应用，因此本文还提出了当前的改进策略、挑战和前景。本综述为药物化学家提供了一个新的途径，即用简单、低成本的材料来调节核壳 MOF 材料的结构特征，以改善人类的生活。
